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This is a prospective, multisite (but all within the UTSW IRB), observational study assessing the relationship of hope to anxiety and depression, QoL, and social support over time in the first year after cancer diagnosis or relapse in AYA (ages 15-29 years of age).
The principal investigators' ongoing work suggests hope is a target for intervention to improve quality of life (QoL) and reduce anxiety and depression (A/D) among adolescents/young adults (AYA). No study to the investigators' knowledge has evaluated the promising impact of hope interventions in AYA cancer patients. To address this gap, the investigators will expand the investigators' prior research on hope, A/D, and QoL to AYA receiving care across three diverse healthcare systems.
Patients will be approached for participation within 3 months of their initial/relapse cancer diagnosis. Eligible patients (and the parent/caregiver for minor patients) will be approached in a private area of the clinic or hospital room to explain the research aims and informed consent process. After obtaining informed consent/assent (from parents if patients are under 18, from AYA if patient is 18 or older), participants (patients) will utilize an iPad to complete measures via Redcap.
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| Measure | Description | Time Frame |
|---|---|---|
| Feasibility of a multi-site, multiple time-point psychosocial study for AYA with cancer |
| up to 12 months (+/- one 4 weeks) following enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between hope and quality of life (QoL) in AYA cancer patients | - Hypothesis a: Hope (as measured by Snyder's (1991) Hope Scale, higher scores indicate higher hope) will be positively correlated to QoL (Pediatric Quality of Life Inventory 3.0 - Cancer Module, PedsQL, Varni, 2002; higher scores indicate better quality of life) | up to 12 months (+/- one 4 weeks) following enrollment |
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Inclusion Criteria:
Exclusion Criteria:
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Adolescents and young adults newly diagnosed as having a malignancy
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| Name | Affiliation | Role |
|---|---|---|
| Julie Germann, Ph.D. | University of Texas Southwestern Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UT Southwestern Medical Center / Children's Medical Center | Dallas | Texas | 75235 | United States |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D003863 | Depression |
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001523 | Mental Disorders |
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| Correlation between hope and social support (SS) in AYA cancer patients | - Hypothesis a: Hope (as measured by Snyder's (1991) Hope Scale, higher scores indicate higher hope) will be positively correlated to SS (Multidimensional Perceived Social Support Scale (MPSSS; Zimet, Dahlem, Zimet, Farley, 1988); higher scores indicate higher social support) | up to 12 months (+/- one 4 weeks) following enrollment |
| Correlation between hope and anxiety and depression (A/D) in AYA cancer patients | - Hypothesis a: Hope (as measured by Snyder's (1991) Hope Scale, higher scores indicate higher hope) will be inversely correlated to A/D (The Four-Item Patient Health Questionnaire for Anxiety and Depression (PHQ-4; Kroenke, Spitzer, Williams, & Löwe, B. (2009); higher scores indicate greater symptoms of anxiety/depression). | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of medical factors (treatment) on hope in AYA with cancer | - Hypothesis a: Medical severity (type of treatment (chemotherapy, surgery, radiation) will be inversely related to hope (The Hope Scale (Snyder et al., 1991); higher scores indicate greater hope) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of medical factors (treatment) on QoL in AYA with cancer | - Hypothesis a: Medical severity (type of treatment (chemotherapy, surgery, radiation) will be inversely related to QoL (Pediatric Quality of Life Inventory 3.0 - Cancer Module (Varni, Burwinkle, Katz, Meeske, & Dickinson, 2002); higher scores indicate greater quality of life) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of medical factors (treatment) on AD in AYA with cancer | - Hypothesis a: Medical severity (type of treatment (chemotherapy, surgery, radiation) will be positively related to A/D (The Four-Item Patient Health Questionnaire for Anxiety and Depression (PHQ-4; Kroenke, Spitzer, Williams, & Löwe, B. (2009); higher scores indicate greater symptoms of anxiety/depression) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of medical factors (treatment) on SS in AYA with cancer | - Hypothesis a: Medical severity (type of treatment (chemotherapy, surgery, radiation) will be inversely related to SS (Multidimensional Perceived Social Support Scale (MPSSS; Zimet, Dahlem, Zimet, Farley, 1988); higher scores indicate greater social support). | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of socieconomic status on hope in AYA with cancer | - Hypothesis a: SES as indicated by insurance status will be inversely related to hope (The Hope Scale (Snyder et al., 1991); higher scores indicate greater hope) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of socieconomic status on QOL in AYA with cancer | - Hypothesis a: SES as indicated by insurance status will be inversely related to QoL (Pediatric Quality of Life Inventory 3.0 - Cancer Module (Varni, Burwinkle, Katz, Meeske, & Dickinson, 2002); higher scores indicate greater quality of life) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of socieconomic status on AD in AYA with cancer | - Hypothesis a: SES as indicated by insurance status will be positively related to A/D (The Four-Item Patient Health Questionnaire for Anxiety and Depression (PHQ-4; Kroenke, Spitzer, Williams, & Löwe, B. (2009); higher scores indicate greater symptoms of anxiety/depression) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of socieconomic status on SS in AYA with cancer | - Hypothesis a: SES as indicated by insurance status will be inversely related to SS (Multidimensional Perceived Social Support Scale (MPSSS; Zimet, Dahlem, Zimet, Farley, 1988); higher scores indicate greater social support). | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact sex on hope in AYA with cancer | - Hypothesis a: sex will be inversely related to hope (The Hope Scale (Snyder et al., 1991); higher scores indicate greater hope) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact sex on QoL in AYA with cancer | - Hypothesis a: sex will be inversely related to QoL (Pediatric Quality of Life Inventory 3.0 - Cancer Module (Varni, Burwinkle, Katz, Meeske, & Dickinson, 2002); higher scores indicate greater quality of life) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact sex on AD in AYA with cancer | - Hypothesis a: sex will be positively related to A/D (The Four-Item Patient Health Questionnaire for Anxiety and Depression (PHQ-4; Kroenke, Spitzer, Williams, & Löwe, B. (2009); higher scores indicate greater symptoms of anxiety/depression) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact sex on SS in AYA with cancer | - Hypothesis a: sex will be inversely related to SS (Multidimensional Perceived Social Support Scale (MPSSS; Zimet, Dahlem, Zimet, Farley, 1988); higher scores indicate greater social support). | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of age on hope in AYA with cancer | - Hypothesis a: age will be inversely related to hope (The Hope Scale (Snyder et al., 1991); higher scores indicate greater hope) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of age on QoL in AYA with cancer | - Hypothesis a: age will be inversely related to QoL (Pediatric Quality of Life Inventory 3.0 - Cancer Module (Varni, Burwinkle, Katz, Meeske, & Dickinson, 2002); higher scores indicate greater quality of life) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of age on AD in AYA with cancer | - Hypothesis a: age will be positively related to A/D (The Four-Item Patient Health Questionnaire for Anxiety and Depression (PHQ-4; Kroenke, Spitzer, Williams, & Löwe, B. (2009); higher scores indicate greater symptoms of anxiety/depression) | up to 12 months (+/- one 4 weeks) following enrollment |
| Determine the impact of age on SS in AYA with cancer | - Hypothesis a: age will be inversely related to SS (Multidimensional Perceived Social Support Scale (MPSSS; Zimet, Dahlem, Zimet, Farley, 1988); higher scores indicate greater social support). | up to 12 months (+/- one 4 weeks) following enrollment |