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General anesthesia induces hemodynamic changes, notably a reduction of arterial blood pressure going up to 30%, that may impact cerebral perfusion and oxygenation.The purpose of this study is to assess the impact of anesthesia on the cerebral oxygenation, the perfusion of the brain (assessed with transcranial doppler), and the depth of anesthesia in children between 6 months and 5 years old during the induction of general anesthesia (induced with sevoflurane and/or IV agents). It is expected that the cerebral hemodynamic will be maintained despite systemic variations.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| General anesthesia | Procedure | Children under general anesthesia for an elective surgery, aged between 6 months and 5 years old, ASA 1-2. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in NIRS values during induction | Changes in cerebral Near infra-red spectrometry values | baseline and 1 minute after intubation |
| Changes in cerebral velocity of the middle cerebral artery during induction | baseline and 1 minute after intubation | |
| Changes of Response Entropy (RE) value during induction | baseline and 1 minute after intubation | |
| Changes of State Entropy (SE) value during induction | Depth of anesthesia | baseline and 1 minute after intubation |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in NIRS values after induction | At 1 minute, 3 minutes after intubation and at the start of surgery | |
| Change in cerebral velocity of the middle cerebral artery after induction | At 1 minute, 3 minutes after intubation and at the start of surgery |
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Inclusion Criteria:
Exclusion Criteria:
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Children under general anesthesia for an elective surgery, aged between 6 months and 5 years old, ASA 1-2.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sainte Justine Hospital | Montreal | Quebec | H3T1C5 | Canada |
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| ID | Term |
|---|---|
| D000768 | Anesthesia, General |
| ID | Term |
|---|---|
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
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| Changes of arterial blood pressure during induction | At baseline and 1 minute after intubation |
| Changes of Response Entropy (RE) values after induction | At 1 minute, 3 minutes after intubation and at the start of surgery |
| Endtidal Co2 after induction | 1 minute after intubation |
| Changes of State Entropy (SE) value after induction | At 1 minute, 3 minutes after intubation and at the start of surgery |