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The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Main Arm | Experimental | In each patient, under ongoing standard general anesthesia in a stable state, EtCO2 is manually modified to reach predefined values, and after waiting until cerebral blood flow has reached steady state, NIRS and DTC values are noted. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EtCO2 modification | Procedure | Controlled modification of EtCO2 through modification of ventilation parameters under general anesthesia without spontaneous breathing |
|
| Measure | Description | Time Frame |
|---|---|---|
| NIRS variation | Near-Infrared Spectroscopy value variation after EtCO2 modification | 5 to 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| DTC variation | Transcranial Doppler values variation after EtCO2 modification | 5 to 10 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bruno Greff, MD | Sainte Justine's Hospital | Principal Investigator |
| Ossam Rhondali, MD | Sainte Justine's Hospital | Study Director |
| Jose Luis Martinez, MD | Sainte Justine's Hospital | Study Chair |
| Chantal Crochetière, MD | Sainte Justine's Hospital | Study Chair |
| Valérie Gaspard, MD | Sainte Justine's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sainte Justine's Hospital | Montreal | Quebec | H3T 1C5 | Canada |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_ICF | Yes | No | Yes | Study Protocol and Informed Consent Form | Sep 13, 2016 | Jun 21, 2018 | Prot_ICF_000.pdf |
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Cerebral blood flow is measured in each patient at 3 different, controlled levels of end-tidal CO2
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Patient is under general anesthesia
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