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| Name | Class |
|---|---|
| Société des Produits Nestlé (SPN) | INDUSTRY |
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Participants will undergo 3 Positron Emission Tomography (PET) scans in 3 different conditions :
This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt with or without food intake in middle-aged adults. Participants will have 3 different PET scan to perform :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Fasting without exogenous ketone salt supplement | |
| Fasting with exogenous ketone salt supplement | Experimental | Fasting with exogenous ketone salt supplement |
|
| Post-Prandial with exogenous ketone salt supplement | Experimental | Post-Prandial with exogenous ketone salt supplement |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fasting with exogenous ketone salt supplement | Dietary Supplement | Participants will have to take 2 doses of supplement, one 75 minutes before the scan and one 30 minutes before the scan. |
| Measure | Description | Time Frame |
|---|---|---|
| 11C-Acetoacetate Heart Ketone uptake | Heart ketone uptake measured by PET scan | 60 minutes |
| 11C-Acetoacetate Kidney ketone uptake | Kidney ketone uptake measured by PET scan | 60 minutes |
| Cardiac Functions, telediastolic volume | telediastolic volume | 60 minutes |
| Cardiac Functions, telesystolic volume | telesystolic volume | 60 minutes |
| Cardiac functions, ejection fraction | Ejection fraction | 60minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma ketone | Plasma ketone concentration | 60 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rearsh Centre on Aging | Sherbrooke | Quebec | J1H4C4 | Canada |
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| ID | Term |
|---|---|
| D019518 | Postprandial Period |
| ID | Term |
|---|---|
| D004068 | Digestive System Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
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Each participant will have to do the 3 acute interventions
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| Post-Prandial with exogenous ketone salt supplement | Dietary Supplement | Participants will have to take 2 doses of supplement, one 75 minutes before the scan and one 30 minutes before the scan and they will have a liquid meal 20 minutes before the scan. |
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