Heart and Kidney Ketones Metabolism

Exogenous Ketone Salt on Heart and Kidney Ketone Metabolism Measured by Positron Emission Tomography

Participants will undergo 3 Positron Emission Tomography (PET) scans in 3 different conditions :

1. Fasting without exogenous ketone salt
2. Fasting with exogenous ketone salt supplement
3. Post-Prandial with exogenous ketone salt supplement.

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt with or without food intake in middle-aged adults. Participants will have 3 different PET scan to perform :

1. Fasting without exogenous ketone salt
2. Fasting with exogenous ketone salt supplement
3. Post-Prandial with exogenous ketone salt supplement.

Inclusion Criteria:

• Aged between 45 and 64
• Generally Healthy
• BMI between 18.5 and 27

Exclusion Criteria:

• All drugs taken on a daily basis
• Diabetes or pre-diabetes
• Digestive dysfunction
• Pregnancy or lactation
• Allergy to the supplement
• Participate in an intensive physical exercise training (more than three times a week)
• Being on a ketogenic diet or consumption of ketogenic supplement.
• More than 2 alcoholic beverages each day
• Any clinically significant anomaly in the blood profile
• Smoking
• Claustrophobia
• Being enrolled in another interventional research project or in a PET research project
• Unable to lie dorsally supine for at least 60 minutes