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The study aimed to evaluate the association between the obesity grade and the age of the first acute coronary syndrome (ACS). The effect of cardiovascular (CV) risk factors and the age of first ACS in patients with severe obesity was also examined. Consecutive patients with diagnosis of first episode of ACS were prospectively enrolled in 2014 to 2024.Cardiovascular risks of patients will be determined according to clinical and laboratory evaluation and patients were categorized by their body mass indices (BMI). Independent variables that effected the age of first ACS were examined by linear regression analysis
In the first stage, the first ACS diagnosis of the patients will be tried to be clarified. It will be tried to clarify whether the patients have had ACS before, according to their history, ecg echo and coronary angiography findings. Patients with previous ACS or uncertain ACS diagnosis will not be included in the study.
In the second stage, cardiovascular risk burdens of patients for whom the initial ACS diagnosis is clear will be revealed. Smoking, diabetes mellitus (DM), hypertension (HT), psychological stress, socio-economic status, migration history, cholesterol parameters will be determined. The duration and severity of these risk factors will be determined. In the final model, each risk factor will be examined in detail with its sub-tabs and the effect of each risk factor will be examined separately.
Eventually, a model will be developed that allows predicting the first ACS age. The shortcomings of this model and the narrow scope of the definition of the population will be determined and the direction will be determined for the studies that improve these points.
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| Measure | Description | Time Frame |
|---|---|---|
| Determining the effect of cardiovascular risk factors on the mean age of the first acute coronary syndrome | Detection of the effect of gender, smoking, obesity, diabetes, hypertension, psychological stress, socioeconomic status, migration, dyslipidemia on the age of first acute coronary syndrome episode. | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Determining the effect of obesity on the mean age of the first acute coronary syndrome | Grouping will be made to obesity degree (Normal, overweight, obesity severe obesity). The first ACS average age of these groups will be compared. Risk factors affecting this average age will not be revealed by linear regression model. | 6 years |
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Inclusion Criteria:
Exclusion Criteria:
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First acute coronary syndrome patients admitted to the coronary intensive care unit
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Deniz Demirci, MD | Contact | +905056847321 | dddemirci@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Deniz Demirci | Recruiting | Antalya | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34864079 | Derived | Demirci D, Demirci DE, Chi G. Association between obesity grade and the age of the first acute coronary syndrome: Prospective observational study. Int J Cardiol. 2022 Mar 15;351:93-99. doi: 10.1016/j.ijcard.2021.11.080. Epub 2021 Dec 2. |
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| D009765 | Obesity |
| D012907 | Smoking |
| D003075 | Coitus |
| D006949 | Hyperlipidemias |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| Determining the effect of migration on the mean age of the first acute coronary syndrome. |
Do the patients live in the city where they were born. It will be determined whether he migrated from another city. If there is a migration situation, the reasons will be determined. The migration direction will be determined according to the regions. The impact of migration and migration direction on the first ACS age will be determined. |
| 6 years |
| Model for calculating the acute coronary syndrome age | Develop a model that calculates the estimated age of ACS on the basis of cardiovascular risk factors. | 8 years |
| D050177 |
| Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D012725 | Sexual Behavior |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D044882 | Glucose Metabolism Disorders |
| D004700 | Endocrine System Diseases |