This is a national registry study to determine genetics risk factors and serial biomarkers of Acute Coronary Syndrome.

ACS Case Inclusion Criteria:

• Written informed consent has been provided.

• Contact Order Form has been provided.

• Aged 18 years or older.

• Hospitalized within 48 hours of onset of symptoms.

• Diagnosis of STEMI, NSTEMI or UA using the following definitions:

  1.Criteria for STEMI diagnosis:

  1. History of chest pain/discomfort and
  2. Persistent ST-segment elevation (> 30 min) of ≥ 0.1 mV in 2 or more contiguous ECG leads or presumed new left bundle branch block (LBBB) on admission and
  3. Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit.

  2.Criteria for NSTEMI diagnosis:

  1.History of chest pain/discomfort and 2.Lack of persistent ST-segment elevation, LBBB or intraventricular conduction disturbances and 3.Elevation of cardiac biomarkers (CK-MB, troponins): at least one value above the 99th percentile of the local laboratory upper reference limit. 3.Criteria for Unstable Angina diagnosis:

  1. Symptoms of angina at rest or on minimal exercise and

  2. At least 0.5mm ST deviation in at least 2 leads and

  3. No increase in biomarkers of necrosis

  4. OR objective evidence of ischaemia by non-invasive imaging OR significant coronary stenosis as determined by the treating physician at angiography if this is standard practice in study site.

     Case Exclusion Criteria:

     Patients will not be eligible to participate if any of the following exclusion criteria are present:

• UA, STEMI and NSTEMI precipitated by or as a complication of surgery, trauma, or GI bleeding or post-PCI.

• UA, STEMI and NSTEMI occurring in patients already hospitalized for other reasons.

• Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient (e.g. tourist, non-native speaker or does not understand the local language, psychiatric disturbances).

• Presence of serious/severe co-morbidities in the opinion of the investigator which may limit short term (i.e. 6 month) life expectancy.

• Current participation in a randomised interventional clinical trial.

Control Inclusion Criteria:

• Age and gender are matched with cases.
• No Coronary Artery Disease was detected by Coronary CT examination.
• Normal biochemical indicators.

Case-ACS-MACE group consists of patients who was diagnosed as Acute Coronary Syndrome and had a poor prognosis during follow up.

Control-ACS-MACE group consists of patients who was diagnosed as Acute Coronary Syndrome and had a good prognosis during follow up.

Health control group is general population without Acute Coronary Syndrome.