An Observational Study on the Natural Course of Chronic Pancreatitis

The Impact of Genetic and Environmental Factors on the Progression of Chronic Pancreatitis：An Observational Study

To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.

The present study was an observational study aimed to explore the impact of genetic factors (rare pathogenic variants of CP) and environmental factors(smoking and alcohol assumption) on the clinical manifestation and progression of CP. The observation items included the pain patterns, incidence of complications of CP, pancreatic cancer and death.

Inclusion Criteria:

• patients with a diagnosis of chronic pancreatitis
• agree to join the study and provide informed consent

Exclusion Criteria:

• autoimmune pancreatitis
• pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
• the follow-up time less than 2 years
• patients presenting with diabetes and/or steatorrhea at onset of CP.