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| Name | Class |
|---|---|
| Tobacco Related Disease Research Program | OTHER |
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Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization and inflammation/oxidative stress.
On separate days, participants will undergo 3 different exposures: an acute e-cigarette exposure, an acute tobacco cigarette exposure, and a sham (empty e-cigarette) control . Before and after the acute exposure, participants will have blood drawn for inflammation/oxidative stress markers and undergo a 5-minute ECG recording.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PLWH smoker | Experimental | PLWH who smoke will undergo 3 interventions : acute TCIG use, acute ECIG use and acute sham control |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TCIG | Other | Use a TCIG |
| |
| ECIG |
| Measure | Description | Time Frame |
|---|---|---|
| Tpe | interval indicative of ventricular repolarization measured on ECG | Change in Tpe 5 minutes after cigarette use |
| Tpe/QT | interval indicative of ventricular repolarization measured on ECG | Change in Tpe/QT after cigarette use |
| Tpe/QTc | interval indicative of ventricular repolarization measured on ECG | Change in Tpe/QTc after cigarette use |
| Total Cellular Reactive Oxygen Stress | total cellular oxidative stress measured by flow cytometry | within 4 hours of cigarette use |
| Measure | Description | Time Frame |
|---|---|---|
| QT | interval indicative of ventricular repolarization measured on ECG | Change in QT after cigarette use |
| QTc | interval indicative of ventricular repolarization measured on ECG |
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Inclusion Criteria:
Chronic (> 1year) TCIG smoker HIV positive Stable ART Viral count non-detectable CD4 >500
Exclusion Criteria:
Known major illness (heart disease, diabetes, lung or liver disease) Daily recreational drug use, including cannabis >2 alcoholic drinks per day Obesity (>30 kg/m2) Recent (<3 months) infection
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCLA | Los Angeles | California | 890095 | United States | ||
| UCaliforniaLA |
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| ID | Term |
|---|---|
| D000072137 | Vaping |
| D012907 | Smoking |
| D000073869 | Tobacco Smoking |
| D014029 | Tobacco Use Disorder |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D064424 | Tobacco Use |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
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Crossover with 1 week washout
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single (outcomes assessor) code
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| Other |
Use an ECIG |
|
| sham control | Other | Use a sham control (empty ECIG) |
|
| Change in QTc after cigarette use |
| Los Angeles |
| California |
| 90095 |
| United States |
| D001523 |
| Mental Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |