A Study to Evaluate the Efficacy and Safety of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis | NCT04552899 | Trialant

A Study to Evaluate the Efficacy and Safety of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis | NCT04552899 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Documented diagnosis of IPF per the 2018 American Thoracic Society (ATS)/European Respiratory Society (ERS)/Japanese Respiratory Society (JRS)/Latin American Thoracic Society (ALAT) Clinical Practice Guideline

High-resolution computed tomography (HRCT) pattern consistent with the diagnosis of IPF, confirmed by central review of Chest HRCT and central review of any available lung biopsy (LB)

Minimum 6 minute walk distance (6MWD) of 150 meters with maximum use of 6 L/min at sea-level and up-to 8 L/min at altitude of supplemental oxygen while maintaining oxygen saturation of greater than or equal to (>/= )83% during the 6 minute walk test (6MWT) during screening

FVC >/= 45% predicted during screening as determined by the over-reader

Forced expiratory volume in 1 second (FEV1)/FVC ratio greater than (>) 0.70 during screening determined by the over-reader

Diffusing capacity for carbon monoxide (DLCO) >/= 30% and less than or equal to (</=) 90% of predicted at screening as determined by the over-reader

If receiving pirfenidone or nintedanib treatment for IPF, the participant must have been on treatment for at least 3 months and a stable dose for at least 4 weeks prior to screening, and during screening

If not currently receiving nintedanib or pirfenidone treatment (either treatment naïve or having previously taken and discontinued) must have discontinued such treatment >/= 4 weeks prior to screening and during screening

Anticipated life expectancy of at least 12 months at baseline

Participant and investigator considered all medicinal treatment options and/or possibly lung transplantation prior to considering participation in the study.

For women of childbearing potential (excluding participant enrolling in Japan): agreement to remain abstinent or use contraception

For men: agreement to remain abstinent or use a condom, and agreement to refrain from donating sperm

Anticipated life expectancy of at least 12 months at baseline, according to the investigator's judgment

For participant enrolled in the extended China enrollment phase: current resident of mainland China, Hong Kong, or Taiwan, and of Chinese ancestry

Exclusion Criteria:

Evidence of other known causes of Interstitial Lung Disease (ILD)

FVC% predicted value showing repeated increase in the 6 months period prior to screening and including screening value

Emphysema present on greater than or equal to (>/=) 50% of the HRCT, or the extent of emphysema is greater than the extent of fibrosis, according to central review of the HRCT

Receiving nintedanib in combination with pirfenidone

Received cytotoxic, immunosuppressive, cytokine modulating, or receptor antagonist agents (including but not limited to methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide, cyclosporine or other steroid sparing agent) within 4 weeks prior to or during screening

Receiving systemic corticosteroids equivalent to prednisone > 10 mg/day or equivalent within 2 weeks prior to or during screening

Acute respiratory or systemic bacterial, viral, or fungal infection either during screening or prior to screening and not successfully resolved 4 weeks prior to screening visit

Participants with active or latent tuberculosis (confirmed within the 6 months prior to or during screening, by a positive screening test [interferon gamma release assay])

Resting oxygen saturation of < 89% using up to 4 L/min of supplemental oxygen at sea level and up to 6 L/min at altitude (>/= 5000 feet [1524 meters] above sea level) during screening

Class IV New York Heart Association chronic heart failure

Historical evidence of left ventricular ejection fraction < 35%

Presence of pulmonary hypertension that, in the investigator's opinion, would substantially limit the ability to comply with study requirements or may influence any of the safety or efficacy assessments included in the study

Cardiopulmonary rehabilitation program based on exercise training that has been completed within 8 weeks prior to screening or planned to start during the participant enrollment in this trial

History of smoking, alcohol or substance abuse disorder, or a malignancy

Previous treatment with PRM-151

Clinically significant abnormality on ECG during screening that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant including prolonged corrected QT interval > 450 ms (for men) or > 470 ms (for women) on ECG during screening based on the Fridericia correction formula

Clinically significant laboratory test abnormalities during screening (hematology, serum chemistry, and urinalysis) that, in the opinion of the investigator, may pose an additional risk in administering study drug to the participant

Pregnant or breastfeeding, or become pregnant during the study or within 8 weeks after the final dose of PRM-151

Women of childbearing potential (Only for participants enrolling in Japan)

University of Alabama at Birmingham

Birmingham, Alabama 35294, United States

Banner University Medical Center Phoenix; Main Pharmacy

Phoenix, Arizona 85006, United States

Lovelace Scientific Resources, Inc.

Phoenix, Arizona 85016, United States

UC Irvine Medical Center

Orange, California 92868, United States

Stanford Hospital and Clinics

Palo Alto, California 94304, United States

University of California Davis

Sacramento, California 95817, United States

Inst. of Healthcare Assessment, Inc.

San Diego, California 92120, United States

UCSF Medical Center

San Francisco, California 94143-0748, United States

Paloma Medical Group

San Juan Capistrano, California 92675, United States

William Sansum Diabetes Center

Santa Barbara, California 93105, United States

University of Colorado - Anschutz Medical Campus (University of Colorado Health Sciences Center)

Aurora, Colorado 80045, United States

National Jewish Health Medical Center

Denver, Colorado 80045-2541, United States

Yale New Haven Hospital

New Haven, Connecticut 06510, United States

Georgetown University Medical Center

Washington D.C., District of Columbia 20007, United States

Meris Clinical Research

Brandon, Florida 33511-5719, United States

Florida Lung, Asthma and Sleep Specialists (FLASS) - Celebration

Celebration, Florida 34747-1818, United States

Advanced Pulmonary & Sleep Research Institute of Florida

Daytona Beach, Florida 32117, United States

University of Florida Division of Pulmonary, Critical Care, and Sleep Medicine

Gainesville, Florida 32608-3928, United States

Malcom Randall VA Medical Center

Gainesville, Florida 32608, United States

University of Florida Health Pulmonology - Jacksonville

Jacksonville, Florida 32209, United States

Advanced Pulmonary Research Institute

Loxahatchee Groves, Florida 33470-9216, United States

San Marcus Research Clinic Inc.

Miami, Florida 33014, United States

Renstar Medical Research

Ocala, Florida 34470, United States

Central Florida Pulmonary Group, PA

Orlando, Florida 32803, United States

Sarasota Memorial Health Care System; Cancer Research Program

Sarasota, Florida 34239, United States

University of South Florida

Tampa, Florida 33612, United States

Integral ? Clinical Trial Solutions

Weston, Florida 33327, United States

Clinical Site Partners Orlando

Winter Park, Florida 32789, United States

Emory University

Atlanta, Georgia 30322, United States

Piedmont Healthcare Pulmonary and Critical Care Research

Austell, Georgia 30106, United States

NorthShore University HealthSystem

Evanston, Illinois 60201, United States

Indiana Univ School of Med

Indianapolis, Indiana 46202, United States

University of Iowa Hospitals and Clinics; Investigational Drug Services

Iowa City, Iowa 52242, United States

University of Kansas Medical Center

Kansas City, Kansas 66160, United States

University of Louisville Health Sciences Center

Louisville, Kentucky 40202, United States

Massachusetts General Hospital

Boston, Massachusetts 02114, United States

Brigham & Women'S Hospital

Boston, Massachusetts 02115, United States

Covenant Medical Center - Cooper

Saginaw, Michigan 48602-5383, United States

University of Minnesota Medical Center

Minneapolis, Minnesota 29425-8911, United States

Mayo Clinic Rochester

Rochester, Minnesota 55902, United States

The Lung Research Center

Chesterfield, Missouri 63017-3625, United States

Washington University

St Louis, Missouri 63128, United States

University of Nebraska Medical Center

Omaha, Nebraska 68198-0600, United States

Pulmonary & Allergy Associates

Summit, New Jersey 07901-4055, United States

Lenox Hill Hospital

New York, New York 10075, United States

American Health Research Inc.

Charlotte, North Carolina 28277, United States

Duke University Medical Center

Durham, North Carolina 27710, United States

Pulmonix Research

Greensboro, North Carolina 27403-1127, United States

PMG Research of Wilmington

Wilmington, North Carolina 28401, United States

University of Cincinnati Cancer Institute

Cincinnati, Ohio 45219, United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio 44106, United States

Mercy St. Vincent Medical Center

Toledo, Ohio 43608, United States

Oregon Health and Science University

Portland, Oregon 97239, United States

Jefferson University Physicians (JUP) - Jefferson Pulmonary

Philadelphia, Pennsylvania 19107, United States

Temple University Medical Center

Philadelphia, Pennsylvania 19140-4105, United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania 15213, United States

Medical University of South Carolina Hospital

Charleston, South Carolina 29425, United States

SleepMed of South Carolina

Columbia, South Carolina 29201-2953, United States

Lowcountry Lung and Critical Care

North Charleston, South Carolina 29406, United States

Spartanburg Medical Center

Spartanburg, South Carolina 29303, United States

Vanderbilt University Medical Center

Nashville, Tennessee 37212, United States

Horizon Clinical Research Group

Cypress, Texas 77429, United States

Cardiopulmonary Research Science and Technology Institute

Dallas, Texas 75230, United States

University of Texas Southwestern Medical Center; Heart and Lung Clinic

Dallas, Texas 75390-8575, United States

University of Texas Medical Branch; Cardiology Department

Galveston, Texas 77555, United States

DCOL Center for Clinical Research

Longview, Texas 75605-2410, United States

Metroplex Pulmonology & Sleep Center

McKinney, Texas 75069, United States

Audie L. Murphy VA Hospital, STVHCS

San Antonio, Texas 78229, United States

University Of Utah Hosp & Clin; Investigational Pharmacy

Salt Lake City, Utah 84132, United States

Inova Fairfax Hospital/IHVI; Cardiology

Falls Church, Virginia 22042, United States

Virginia Commonwealth University

Richmond, Virginia 23219-1901, United States

University of Wisconsin-Madison

Madison, Wisconsin 53792, United States

Hospital Britanico de Buenos Aires

Ciudad Autonoma Buenos Aires, C1284AEB, Argentina

Fundacion Respirar (Centro Medico Dra. De Salvo)

Ciudad Autonoma Buenos Aires, C1426ABP, Argentina

Instituto de Medicina Respiratoria, IMeR; Clinic/Outpatient Facility

Córdoba, X5003DCE, Argentina

Centro Medico de Enfermedades Respiratorias (CEMER)

Florida, Buenos Aires, B1602DQD, Argentina

Centro de estudios respiratorios

Mar del Plata, B7600CLK, Argentina

Fundacion Scherbovsky

Mendoza, M5500AYB, Argentina

INSARES

Mendoza, Mendoza City, M5500CCG, Argentina

Investigaciones en Patologias Respiratorias

San Miguel de Tucumán, T4000IAR, Argentina

Royal Prince Alfred Hospital

Camperdown, New South Wales 2050, Australia

Cairns Base Hospital; Cancer Care Centre

Cairns, Queensland 4870, Australia

Lung Research Queensland

Nundah, Queensland 4101, Australia

Princess Alexandra Hospital

Woolloongabba, Queensland 4102, Australia

The Queen Elizabeth Hospital

Adelaide, South Australia 5011, Australia

Austin Hospital; Cancer Clinical Trials Centre

Melbourne, Victoria 3084, Australia

Monash Medical Centre; Medicine

Melbourne, Victoria 3186, Australia

The Alfred Hospital

Prahan, Victoria 3181, Australia

Fiona Stanley Hospital

Murdoch, Western Australia 6150, Australia

Klinikum Klagenfurt am Wörthersee; 2. Medizinische Abteilung

Klagenfurt, 9020, Austria

Landeskrankenhaus Salzburg; Gynäkologie Und Onkologie

Salzburg, 5020, Austria

ULB Hôpital Erasme

Brussels, 1070, Belgium

Cliniques Universitaires Saint-Luc; Pharmacy

Brussels, 1200, Belgium

UZ Leuven

Leuven, 3000, Belgium

C. H. U. Sart-Tilman; Laboratory

Liège, 4000, Belgium

CHU UCL Namur / site Godinne

Yvoir, B5530, Belgium

Hospital das Clinicas - UFMG

Belo Horizonte, Minas Gerais 31270-901, Brazil

Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul 90020-090, Brazil

University of Alberta Hospital

Edmonton, Alberta T6G 1Z1, Canada

Synergy Respiratory Care

Sherwood Park, Alberta T8H ON2, Canada

Kelowna Respiratory and Allergy Clinic

Kelowna, British Columbia V1W 1V3, Canada

Vancouver General Hospital; Gordon and Leslie Diamond Health Care

Vancouver, British Columbia V5Z 1L7, Canada

Eastern Health - General Hospital

St. John's, Newfoundland and Labrador A1B 3V6, Canada

The Rhema Research Institute

Owen Sound, Ontario N4K 6M9, Canada

Dr. Syed Anees Medicine Profession Corporation

Windsor, Ontario N8X 1T3, Canada

Centre Hospitalier de l'Universite de Montreal - Notre - Dame Hos pital

Montreal, Quebec H2X 1R9, Canada

McGill University, Montreal Chest Institute; Viral and other Infectious

Montreal, Quebec H2X2P4, Canada

C.I.C. Mauricie

Trois-Rivières, Quebec G8T 7A1, Canada

CMU-Beijing Chao-Yang Hospital-Beijing Institute of Respiratory Medicine

Beijing, 100020, China

China-Japan Friendship Hospital

Beijing, 100029, China

Beijing Friendship Hospital Affiliated of Capital University of Medical Science

Beijing, 100050, China

Peking University Third Hospital

Beijing, 100191, China

Peking Union Medical College Hospital; Pharmacy

Beijing, 100730, China

Xiangya Hospital Central South University

Changsha, 410008, China

The Second Xiangya Hospital of Central South University

Changsha, 410011, China

The Third Xiangya Hospital Of Central South University

Changsha, 410013, China

West China Hospital, Sichuan University

Chengdu, 610041, China

Southern Medical University Nanfang Hospital

Guangdong Province Guangzhou City, 510515, China

The First Affilicated Hospital, Sun Yat-sen University

Guangzhou, 510080, China

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, 510120, China

1st Affiliated Hospital of Zhejiang University; Clinical Trial Pharmacy

Hangzhou, 310003, China

Inner Mongolia Autonomous Region People's Hospital

Hohhot, 010011, China

Qilu Hospital of Shandong University

Jinan, 250012, China

The 1st Affiliated Hospital of Nanchang Unversity

Nanchang, 330006, China

Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

Nanjing, 210008, China

Ningbo First Hospital

Ningbo, 315010, China

Ruijin Hospital Shanghai Jiaotong University School of Medicine

Shanghai, 200025, China

Huadong Hospital Affiliated to Fudan University

Shanghai, 200040, China

Shanghai Pulmonary Hospital

Shanghai, 200433, China

China Medical University (CMU) First Affiliated Hospital

Shenyang, 110001, China

Shengjing Hospital of China Medical University

Shenyang, 110004, China

Hebei Medical University - The Second Hospital

Shijiazhuang, 050004, China

Tianjin Medical University General Hospital

Tianjin, 300052, China

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, 430030, China

Wuxi People's Hospital

Wuxi, 214023, China

Tangdu Hospital, The Fourth Military Medical University; Neurology Department

Xi'an, 710038, China

Qinghai Provincial People?s Hospital

Xining, 810007, China

Henan University of Traditional Chinese Medicine (HUTCM) The First Affiliated Hospital

Zhengzhou, 450000, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, 450052, China

Fakultní Nemocnice Brno

Brno, 625 00, Czechia

Fakultni nemocnice Olomouc

Olomouc, 779 00, Czechia

Fakultni Nemocnice Plzen - Klinika Pneumologie a Ftizeologie

Pilsen, 305 99, Czechia

Thomayerova nemocnice; Lekarna - pavilon H

Prague, 140 00, Czechia

Nemocnice Na Bulovce

Prague, 180 01, Czechia

Krajská nemocnice T. Bati, a. s.

Zlín, 762 75, Czechia

Aarhus Universitetshospital Skejby

Aarthus N, 8200, Denmark

Gentofte Hospital

Hellerup, 2900, Denmark

Odense Universitetshospital

Odense C, 5000, Denmark

Turku University Hospital

Turku, 20521, Finland

Hopital Avicenne

Bobigny, 93000, France

Centre Hospitalier Regional Universitaire de Brest - Hopital de la Cavale Blanche

Brest, 29200, France

Hopital Louis Pradel

Bron, 69677, France

Hospital d Instructions des Armees Percy

Clamart, 92141, France

CHU Dijon Bourgogne Hôpital François Mitterand

Dijon, 21000, France

CHU de Grenoble - Hôpital André Michallon; Pole Pharmacie

La Tronche, 38700, France

Centre Hospitalier Regional Universitaire de Lille

Lille, France

Servie de Pneumologie et centre de Transplantation Pulmonaire

Marseille, 13354, France

CHU de Montpellier Hopital Arnaud de Villeneuve; de Génétique

Montpellier, 34295, France

CHU Nice - Hôpital Pasteur 2

Nice, 06000, France

Hopital Bichat Claude Bernard; CIC

Paris, 75877, France

European Hospital Georges Pompidou (HEGP)

Paris, 75908, France

Hopital Haut Leveque

Pessac, 33600, France

Centre Hospitalier Universitaire de Reims; l'Hopital Maison Blanche

Reims, 51092, France

CHU de Rennes - Hopital de Pontchaillo

Rennes, 35033, France

CHU Tours - Hôpital Bretonneau; Pharmacie

Tours, 37044, France

Zentralklinik Bad Berka GmbH; Pneumologie

Bad Berka, 99437, Germany

Evang. Lungenklinik Berlin Klinik für Pneumologie

Berlin, 13125, Germany

Universitatsklinikum Essen; Innere Klinik

Essen, 45122, Germany

IFS - Interdisziplinäres Facharztzentrum; Institut für klinische Forschung Pneumologie

Frankfurt am Main, 60596, Germany

Universitatsklinikum Gießen und Marburg GmbH

Giessen, 35385, Germany

Medizinische Hochschule Hannover; Zentrum Innere Medizin - Klinik fur Pneumologie

Hanover, 30625, Germany

Thoraxklinik-Heidelberg gGmbH; Apotheke der Thoraxklinik

Heidelberg, 69126, Germany

Universitätsklinikum des Saarlandes; Klinik für Augenheilkunde

Homburg/Saar, 66424, Germany

Lungenfachklinik Immenhausen

Immenhausen, 34376, Germany

Universitatsklinikum Leipzig; Apotheke

Leipzig, 04103, Germany

IKF Pneumologie Mainz Helix Medical Excellence Center Mainz

Mainz, 55128, Germany

Praxis für Pneumologie Dr. Silke Mronga & Dr. Lukas Jerrentrup

Marburg, 35037, Germany

Lungenklinik Münnerstadt, Thoraxzentrum Bezirk Unterfranken

Münnerstadt, 97702, Germany

Krankenhaus Bethanien gGmbH

Solingen, 42699, Germany

Evangelismos Hospital; Department of Critical Care and Pulmonary Services

Athens, 106 76, Greece

Attikon University General Hospital

Chaïdári, 124 62, Greece

University General Hospital of Heraklion

Heraklio, 711 10, Greece

University Hospital of Ioannina; Pulmonology Department

Ioannina, 455 00, Greece

Hospital is University General Hospital of Larissa

Larissa, 41110, Greece

Athens Medical Center

Marousi, 151 25, Greece

University General Hospital of Patras

Pátrai, 265 00, Greece

"General hospital of Chest Diseases ""Sotiria"", 7th Pulmonary Clinic "

Sotiria Athens, 115 27, Greece

General Hospital of Thessaloniki G. Papanikolaou

Thessaloniki, 57010, Greece

Prince of Wales Hospital; Dept. of Medicine & Therapeutics

Hong Kong, Hong Kong

The University of Hong Kong; Queen Mary Hospital

Hong Kong, Hong Kong

Semmelweis University

Budapest, 1081, Hungary

Debreceni Egyetem

Debrecen, 4032, Hungary

Markusovszky Egyetemi Oktatokorhaz ; SZEMESZET

Szombathely, 9700, Hungary

Szent Borbala Korhaz

Tatabánya, 2800, Hungary

Tudogyogyintezet Torokbalint; Onkologiai és Jarobeteg Centrum

Törökbálint, 2045, Hungary

Barzilai Medical Center; Neurology Department

Ashkelon, 7830604, Israel

Ben-Gurion University of the Negev - Soroka University Medical Center - Pulmonology Institute

Beersheba, 8410101, Israel

Shamir medical center

Be’er Ya‘aqov, 0070300, Israel

Rambam Health Care Campus

Haifa, 3109600, Israel

Bnai Zion Medical Center; Internal Medicine

Haifa, 3339419, Israel

Carmel Medical Center; Obstetrics and Gynecology

Haifa, 34362, Israel

Edith Wolfson Medical Center

Holon, 5822012, Israel

Shaare Zedek Medical Center; Nrphrology Dept.

Jerusalem, 9103102, Israel

Hadassah Medical Center

Jerusalem, 9112001, Israel

Meir Medical Center

Kfar Saba, 4428164, Israel

Rabin Medical Center

Petach Tiqwa, 4941492, Israel

The Chaim Sheba Medical Center

Ramat Gan, 5211401, Israel

Kaplan Medical Center

Rehovot, 7610001, Israel

Tel-Aviv Sourasky Medical Center; Department of Pulmonary

Tel Aviv, 64239, Israel

Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, Abruzzo 24060, Italy

Policlinico Riuniti di Foggia - Department of Medical and Surgical Sciences - University of Foggia

Foggia, Apulia 71122, Italy

Ospedale di Ostuni - Pneumologia

Ostuni, Apulia 72017, Italy

AORN Ospedali dei Colli Ospedale Monaldi; UOC Pneumologia ad indirizzo Oncologico

Naples, Campania 80131, Italy

Azienda Ospedaliera Dei Colli

Naples, Campania 80131, Italy

Azienda Ospedaliera Universitaria Federico II

Naples, Campania 80131, Italy

Università degli Studi di Napoli Federico II; Dipartimento di Scienze Oftalmologiche

Naples, Campania 80131, Italy

Ospedale Morgagni Pierantoni; Patologia clinica

Forlì, Emilia-Romagna 47100, Italy

A.O.U. Policlinico di Modena

Modena, Emilia-Romagna 40124, Italy

Azienda Sanitaria Universitaria Integrata di Trieste

Trieste, Friuli Venezia Giulia 34125, Italy

Policlinico Tor Vergata - U.O.C. Malattie Apparato Respiratorio

Rome, Lazio 00133, Italy

Fondazione Policlinico Universitario A Gemelli; Servizio di Farmacia

Rome, Lazio 00168, Italy

"Asst Rhodense - Unità operativa di pneumologia Ospedale ""Guido Salvini"" "

Garbagnate Milanese, Lombardy, Italy

Ospedale San Giuseppe; U.O. di Pneumologia

Milan, Lombardy 20123, Italy

Asst Santi Paolo E Carlo

Milan, Lombardy 20142, Italy

Ospedale San Gerardo

Monza, Lombardy 20900, Italy

Fondazione IRCCS Policlinico San Matteo Divisione di EmatologiaDipartimento di Onco-Ematologia

Pavia, Lombardy 27100, Italy

A.O.U. S. Luigi Gonzaga; Interstiziopatie Malattie Rare Polmone

Orbassano (TO), Piedmont 10043, Italy

Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino; Ospedale Molinette

Turin, Piedmont 10026, Italy

A.O.U. Sassari; Dip. Medicina Clinica e Sperimentale

Sassari, Sardinia 07100, Italy

Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele

Catania, Sicily 95123, Italy

Az. Osp. Univ. P. Giaccone; UOC di Pneumologia

Palermo, Sicily 90127, Italy

Ismett Istituto Mediterraneo Trapianti E Terapie Alta Specializzazione;Pneumologia

Palermo, Sicily 90127, Italy

Azienda Ospedaliero Universitaria Ospedali Riuniti

Torrette Di Ancona, The Marches 60126, Italy

AOUC Azienda Ospedaliero-Universitaria Careggi; Neurologia 2

Florence, Tuscany 50134, Italy

A.O. Univ. Senese Policlinico S. Maria alle Scotte; Dip. Medicina clinica e Scienze Immunologiche

Siena, Tuscany 53100, Italy

Azienda Ospedale Università Di Padova; Clinica Pneumologica

Padova, Veneto 35128, Italy

University of Padova Ca' Foncello Hospital Immunologic & Respiratory Rare Diseases Center

Treviso, Veneto 31100, Italy

Nagoya University Hospital

Aichi, 466-8560, Japan

Chiba University Hospital

Chiba, 260-8677, Japan

National Hospital Organization Kyushu Medical Center

Fukuoka, 810-8563, Japan

Fukuoka University Hospital

Fukuoka, 814-0180, Japan

Kobe City Medical Center General Hospital

Hyōgo, 650-0047, Japan

National Hospital Organization Himeji Medical Center

Hyōgo, 670-8520, Japan

Kameda Medical Center

Kamogawa, 296-0041, Japan

Kanagawa Cardiovascular and Respiratory Center

Kanagawa, 236-0051, Japan

Nippon Medical School Musashi Kosugi Hospital

Kawasaki-Shi, Japan

Saiseikai Kumamoto Hospital

Kumamoto, 861-4101, Japan

Nagasaki University Hospital

Nagasaki, 852-8501, Japan

National Hospital Organization Ibarakihigashi National Hospital; Center for Clinical Research

Naka-gun, 319-1113, Japan

Kurashiki Central Hospital

Okayama, 710-8602, Japan

National Hospital Organization Kinki-Chuo Chest Medical Center

Sakaishi, 591-8555, Japan

Tosei General Hospital

Seto-shi, 489-8642, Japan

Tenri Hospital

Tenri-Shi, 632-8552, Japan

Jichi Medical University Hospital

Tochigi, 329-0498, Japan

Tokushima University Hospital

Tokushima, 770-8503, Japan

Tokyo Medical Ando Dentaluni Hospital Faculty of Medicine; Surgical Oncology

Tokyo, 113-0034, Japan

Center Hospital of the National Center for Global Health and Medicine

Tokyo, 162-0052, Japan

INER- Instituto Nacional de Enfermedades Respiratorias"Ismae

Mexico City, Mexico CITY (federal District) 14080, Mexico

Centro Respiratorio de México

México, Mexico CITY (federal District) 14050, Mexico

Unidad Médica para la Salud Integral UMSI

San Nicolás de los Garza, Nuevo León 66465, Mexico

Unidad de Investigacion CIMA SC

Chihuahua City, 31200, Mexico

CICC Morelia

Morelia, Mexico

VU Medisch Centrum

Amsterdam, 1081 HV, Netherlands

Sint Antonius Ziekenhuis, locatie Nieuwegein

Nieuwegein, 3430 EM, Netherlands

Erasmus Medisch Centrum

Rotterdam, 3000 CA, Netherlands

Auckland City Hospital

Auckland, 1023, New Zealand

NZ Respiratory & Sleep Institute

Auckland, 1051, New Zealand

University of Otago, Christchurch

Christchurch, 8011, New Zealand

Waikato Hospital; Gastro Research

Hamilton, 3240, New Zealand

Tauranga Hospital

Tauranga, 3143, New Zealand

Helse Bergen HF Haukeland universitetssykehus

Bergen, 5053, Norway

Akershus universitetssykehus

Lørenskog, 1478, Norway

Oslo University Hospital HF, Rikshospitalet

Oslo, 0424, Norway

Centrum Medycyny Oddechowej Mroz sp. j.

Bia?ystok, 15-044, Poland

Nasz Lekarz Osrodek Badan Klinicznych

Bydgoszcz, 85-312, Poland

Uniwersytecki Szpital Kliniczny Nr 1 im.N.Barlickiego Oddzial Kliniczny Pneumonologii i Alergologii

Lodz, 90-153, Poland

Hospital de Braga; Centro Clínico Académico (Piso 1, Ala E)

Braga, 4710-243, Portugal

Centro Hospitalar Algarve

Faro, 8000-386, Portugal

Hospital Senhora da Oliveira ? Guimarães, E.P.E

Guimarães, 4835-044, Portugal

Centro Hospitalar Universitario Lisboa Norte - Hospital Pulido Valente

Lisbon, 1769-001, Portugal

Centro Hospitalar do Porto - Hospital de Santo António

Porto, 4099-001, Portugal

Hospital de Sao Joao; Centro de Investigacao

Porto, 4200-319, Portugal

Hospital de Santa Luzia

Porto, 4904-858, Portugal

CHVNG/E_Unidade 1; Servico de Pneumologia

Vila Nova de Gaia, 4434-502, Portugal

Singapore General Hospital

Singapore, 169608, Singapore

Tan Tock Seng Hospital; Oncology

Singapore, 308433, Singapore

University of Cape Town Lung Institute; Lung Clinical Research

Cape Town, 7700, South Africa

Vergelegen Medi-Clinic

Somerset West, 7130, South Africa

Soon Chun Hyang University Hospital Bucheon

Bucheon-si, 420-767, South Korea

The Catholic University of Korea Bucheon St. Mary's Hospital

Gyeonggi-do, 14662, South Korea

Gacheon University Gil Medical Center

Namdong-gu, 21565, South Korea

Seoul National University Bundang Hospital

Seongnam-si, 463-707, South Korea

The Catholic University of Korea Yeouido St. Mary's Hospital; Hematology-Oncology

Seoul, (0)7345, South Korea

Seoul National University Hospital (SNUH) - Medical Oncology Center

Seoul, 03080, South Korea

Soonchunhyang University Hospital

Seoul, 04401, South Korea

Asan Medical Center

Seoul, 05505, South Korea

Samsung Medical Center

Seoul, 06351, South Korea

Korea University Guro Hospital

Seoul, 08308, South Korea

The Catholic University of Korea Seoul St. Mary?s Hospital

Seoul, 6591, South Korea

Hospital Txagorritxu

Vitoria-Gasteiz, Alava 01009, Spain

Hospital Universitario de Bellvitge

L'Hospitalet de Llobregat, Barcelona 08907, Spain

Parc Taulí Sabadell Hospital Universitari

Sabadell, Barcelona 8208, Spain

Hospital Universitario Marques de Valdecilla

Santander, Cantabria 39008, Spain

Complexo Hospitalario Universitario de Santiago (CHUS) - Hospital Clinico Universitario

Santiago de Compostela, LA Coruña 15706, Spain

Hospital Universitario del Henares

Coslada, Madrid 28850, Spain

Hospital Universitario Puerta de Hierro - Majadahonda

Majadahonda, Madrid 28220, Spain

Hospital Universitario Quironsalud Madrid

Pozuelo de Alarcón, Madrid 28223, Spain

Universidad de Navarra - Clinica Universitaria de Navarra (CUN)

Pamplona, Navarre 31008, Spain

Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias 33011, Spain

Hospital Universitario de Canarias

S. Cristobal de La Laguna, Tenerife 38320, Spain

Hospital Galdakao-Usansolo

Galdakao, Vizcaya 48960, Spain

Hospital de la Santa Creu i Sant Pau; Servicio de Neumologia

Barcelona, 08025, Spain

Vall d?Hebron Institute of Oncology (VHIO), Barcelona

Barcelona, 08035, Spain

Hospital Clinic de Barcelona

Barcelona, 08036, Spain

Hospital Germans Trias i Pujol

Barcelona, 08916, Spain

Hospital Virgen de las Nieves; Servicio de Neumologia

Granada, 18014, Spain

Hospital Universitario de La Princesa

Madrid, 28006, Spain

Hospital Universitario La Paz

Madrid, 280146, Spain

Clínica Universidad de Navarra ? Madrid

Madrid, 28027, Spain

Hospital Ramón y Cajal;Servicio de Neumología

Madrid, 28034, Spain

Hosp. Clinico San Carlos

Madrid, 28040, Spain

Hospital Universitario Fundacion Jimenez Diaz.

Madrid, 28040, Spain

Hospital Universitario 12 de Octubre

Madrid, 28041, Spain

Hospital Clinico Universitario Virgen de la Victoria

Málaga, 29010, Spain

Hospital Clinico Universitario de Salamanca

Salamanca, 37007, Spain

Hospital Universitario Virgen del Rocio

Seville, 41013, Spain

Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain

Hospital Arnau de Vilanova (Valencia)

Valencia, 46015, Spain

Hospital Universitari i Politecnic La Fe de Valencia

Valencia, 46026, Spain

Skånes universitetssjukhus Malmö

Malmö, 214 28, Sweden

Inselspital Bern Universitätsklinik für Pneumologie

Bern, 3010, Switzerland

Hopital Neuchatelois Pourtales (Hopitaux Cadolles Pourtales)

Neuchâtel, 2000, Switzerland

Buddhist Tzu Chi Dalin General Hospital; Rheumatology

Chiayi City, 622, Taiwan

Kaohsiung Medical University Hospital; Chung-Ho Memorial Hospital

Kaoshiung City, 807, Taiwan

China Medical University Hospital

Taichung, 40447, Taiwan

National Cheng Kung University Hospital

Tainan, 70457, Taiwan

National Taiwan University Hospital

Taipei, 10002, Taiwan

Far Eastern Memorial Hospital; Department of Clinical Pathology

Taipei, 220, Taiwan

Veterans General Hospital - Taichung

Xitun Dist., 40705, Taiwan

Istanbul Universitesi Onkoloji Enstitüsü Hastanesi

?stanbul, 34093, Turkey (Türkiye)

Cukurova Universitesi Tip Fakultesi Balcali Hastanesi; Balcali

Adana, 1330, Turkey (Türkiye)

Ankara Universitesi Tip Fakultesi Hastaneleri - Cebeci Hastanesi

Ankara, 06620, Turkey (Türkiye)

Uludag Universitesi - Saglik Uygulama ve Arastirrma Merkezi

Bursa, 16059, Turkey (Türkiye)

Gaziantep Universitesi - Sahinbey Arastirma ve Uygulama Hastanesi

Gaziantep, Turkey (Türkiye)

Yedikule Gogus Hastaliklari ve Gogus Cerrahisi EAH;Gogus Hastaliklari

Istanbul, 34020, Turkey (Türkiye)

Ege Universitesi Tip Fakultesi Hastanesi

Izmir, 35100, Turkey (Türkiye)

Dokuz Eylul University Faculty of Medicine; Chest Diseases

Izmir, 35340, Turkey (Türkiye)

Erciyes Üniversitesi T?p Fakültesi

Kayseri, 38039, Turkey (Türkiye)

Kocaeli Universitesi Tip Fakultesi

Kocaeli, 41380, Turkey (Türkiye)

Marmara Universitesi Hastanesi Marmara University Hospital

Maltepe, 34854, Turkey (Türkiye)

Mersin Üniversitesi Tip Fakültesi

Mersin, 33110, Turkey (Türkiye)

Akdeniz University Faculty of Medicine Department of Pulmonology

Muratpasa/Antalya, 07059, Turkey (Türkiye)

Koc Universitesi (KU) Tip Fakultesi (Koc University School of Medicine)

Sariyer, 34450, Turkey (Türkiye)

Municipal Non-Profit Enterprise City Clinical Hospital #16 of Dnipro City Council

Dnipro, Katerynoslav Governorate 49069, Ukraine

National Academy of Medical Science of Ukraine (NAMS); NRCRM

Kyiv, KIEV Governorate 03115, Ukraine

Yanovskyy Inst of Phth. & Pulm; Clinical-functional

Kyiv, 03680, Ukraine

Edinburgh Royal Infirmary; Respiratory Department

Edinburgh, EH16 4SA, United Kingdom

Royal Brompton Hospital; Respiratory Department

London, SW3 6NP, United Kingdom

Manchester University NHS Foundation Trust - Wythenshawe Hospital

Manchester, M23 9LT, United Kingdom

North Manchester General Hospital

Manchester, M8 5RB, United Kingdom