Clinical Efficacy of Combination Therapy Based on High-dose Biapenem in CRKP Infections

Clinical Efficacy of Combination Therapy Based on High-dose Biapenem in CRKP Infections

Carbapenem resistance is a high mortality rate of Klebsiella pneumoniae infection. It has been proved that high-dose carbapenem can reduce mortality and has a certain clinical effect. In this study, a high dose of biapenem was compared to determine whether it had a similar effect than meropenem.

Inclusion Criteria:

• ICU hospitalized for more than 3 days;
• Biapenem used for more than 3 days

Exclusion Criteria:

• Patients who refuse to be included in the group or pregnant women or under the age of 14 or ICU hospitalized for less than 3 days