Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This research intervention aims to examine the effects of prebiotic consumption on changes in behavioral and biological measures of cognition and stress among adults.
Evidence-based dietary strategies provide behavioral means benefiting physical and cognitive function. Pertinent to the proposed work, dietary intake has been recently shown to have the potential to directly influence the gut microbiota composition as well as brain function. Specifically, the consumption of prebiotics or fibers metabolized by gut bacteria may also play a role. These foods are readily available in the marketplace, however, their implications for physical and cognitive function are not clear. Accordingly, the proposed study aims to investigate effects of prebiotic beverage consumption on changes in behavioral and biological measures of cognition and stress among adults.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | 4-5 week period where participant will consume control beverage |
|
| Prebiotic | Experimental | 4-5 week period where participant will consume the intervention beverage |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactose Free 1% Milk | Other | 8 oz of study beverage daily |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Biological markers of stress | Changes in 24-hour urinary cortisol, inflammatory markers (e.g. IL-6, CRP). | 4-5 weeks |
| Behavioral markers of stress | Change in reported questionnaire responses specific to depression, stress, and anxiety using the Depression, Anxiety, and Stress (DASS) Questionnaire. | 4-5 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Gastrointestinal Microbiota composition | Impact on bacterial genera abundances. | 4-5 weeks |
| Gastrointestinal microbiota beta-diversity | Impact on beta-diversity measures |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Hannah Holscher, PhD, RD | University of Illinois at Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Illinois | Urbana | Illinois | 61801 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36841506 | Derived | Mysonhimer AR, Cannavale CN, Bailey MA, Khan NA, Holscher HD. Prebiotic Consumption Alters Microbiota but Not Biological Markers of Stress and Inflammation or Mental Health Symptoms in Healthy Adults: A Randomized, Controlled, Crossover Trial. J Nutr. 2023 Apr;153(4):1283-1296. doi: 10.1016/j.tjnut.2023.02.015. Epub 2023 Feb 24. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D008892 | Milk |
| D056692 | Prebiotics |
| ID | Term |
|---|---|
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
Not provided
Not provided
Participants will pass through 2 arms, control and prebiotic, in a randomized, counterbalanced order.
Not provided
Not provided
Double blind (participant and investigative team)
| Lactose Free 1% Milk + 10 g prebiotic | Other | 8 oz of study beverage supplemented with 5 grams of fructooligosaccharide and 5 grams of galactooligosaccharide |
|
| 4-5 weeks |
| Gastrointestinal Microbiota alpha-diversity | Impact on alpha-diversity measures | 4-5 weeks |
| Cognitive function | Computer tasks will be used to assess working memory, interference control, cognitive flexibility, and hippocampal function/relational memory | 4-5 weeks |
| Sleep | The Pittsburg Sleep Quality Index (PSQI) will also be used to assess sleep, as will actigraphy. | 4-5 weeks |
| D005502 |
| Food |
| D019602 | Food and Beverages |
| D004043 | Dietary Fiber |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D011135 | Polysaccharides, Bacterial |
| D011134 | Polysaccharides |
| D019587 | Dietary Supplements |