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This research intervention aims to examine the effects of a fermented dairy beverage on changes in behavioral and biological measures of cognition and stress among adults.
Evidence-based dietary strategies provide behavioral means benefiting physical and cognitive function. Pertinent to the proposed work, dietary intake has been recently shown to have the potential to directly influence the gut microbiota composition as well as brain function. Specifically, the consumption of probiotics or foods containing healthful microbial cultures (e.g., fermented milk, yogurts, etc.) are increasingly being recognized as modulators of metabolism, cognition, and stress. These foods are readily available in the marketplace, however, their implications for physical and cognitive function are not clear. Accordingly, the proposed study aims to investigate effects of probiotic beverage consumption on changes in behavioral and biological measures of cognition and stress among adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lactose free 1% milk | Placebo Comparator | Diet will be recorded with a 7-day diet record and participants will include an isocaloric study treatment containing lactose free 1% milk consumed once daily over 4-5 weeks as a control. |
|
| Probiotic treatment | Experimental | Diet will be recorded with a 7-day diet record and participants will include an isocaloric fermented milk (probiotic), consumed once daily, over 4-5 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactose Free 1% Milk | Other | isocaloric study treatment containing lactose free 1% milk consumed once daily over 4-5 weeks as a control. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in cortisol as a biomarker of stress | The effects of probiotic consumption on biomarkers of stress | 4-5 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in fecal microbiota populations | The effects of probiotic consumption on fecal microbiota | 4-5 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in cognition | The effects of probioticconsumption on cognition | 4-5 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hannah Holscher, Ph.D. | University of Illinois at Urbana-Champaign | Principal Investigator |
| Naiman Khan, Ph.D. | University of Illinois at Urbana-Champaign | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Illinois | Urbana | Illinois | 61801 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35282787 | Derived | Cannavale CN, Mysonhimer AR, Bailey MA, Cohen NJ, Holscher HD, Khan NA. Consumption of a fermented dairy beverage improves hippocampal-dependent relational memory in a randomized, controlled cross-over trial. Nutr Neurosci. 2023 Mar;26(3):265-274. doi: 10.1080/1028415X.2022.2046963. Epub 2022 Mar 13. |
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Results will be disseminated by journal articles, thesis or academic papers, conference presentations, and sharing with the funding organization. No subject's identity will be disclosed in any presentation or released without their written permission.
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| ID | Term |
|---|---|
| D008892 | Milk |
| ID | Term |
|---|---|
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
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Participants will pass through 2 arms, control and probiotic, in a randomized, counter-balanced order.
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| Probiotic Treatment | Other | Probiotic treatment, consumed once daily, over 4-5 weeks. |
|
| D005502 |
| Food |
| D019602 | Food and Beverages |