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| ID | Type | Description | Link |
|---|---|---|---|
| R01ES032253 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Environmental Health Sciences (NIEHS) | NIH |
| Duke University | OTHER |
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The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy.
Using already collected samples, this study proposes to evaluate changes in immune function in response to air pollution with the use of innovative technologies, to identify the drivers of immune dysfunction and potential modifiable factors, and to determine how these immune findings are associated with pollution exposure and outcomes of disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women- high level pollution | Exposed to high levels of pollution (PM2.5) |
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| Pregnant women- low level pollution | Exposed to low levels of pollution (PM2.5) |
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| Non-pregnant women-high level pollution | Exposed to high levels of pollution (PM2.5) |
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| Non-pregnant women-low level pollution | exposed to low levels of pollution (PM2.5) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| There is no intervention | Other | There is no intervention |
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| Measure | Description | Time Frame |
|---|---|---|
| Difference in immune cell subset identity and function in pregnant vs. non pregnant women exposed to high vs. low pollution over time | 3 years | |
| Identify the epigenetic molecular mechanisms driving immune dysfunction in pregnancy vs. no pregnancy with high vs. low PM2.5 exposure over time | 3 years | |
| Map T cell receptor diversity to immune dysfunction in pregnancy vs non pregnancy with high vs. low PM2.5 exposure over time | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women at 18-25 weeks gestation and non-pregnant women
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| Name | Affiliation | Role |
|---|---|---|
| R. Sharon Chinthrajah, MD | Stanford, Sean N Parker Center for Allergy and Asthma Center at Stanford | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sean N. Parker Center for Allergy & Asthma Research at Stanford University | Palo Alto | California | 94304 | United States |
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Blood samples