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| Name | Class |
|---|---|
| Laboratoire de Psychologie et NeuroCognition | OTHER |
| GIPSA-LAB | OTHER |
| McGill University | OTHER |
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These studies test the hypothesis that frontal areas of the brain participate in the cortical networks involved in the somotosensory processing that happens during speech motor learning.
This work aims to study the role of sensory systems in human motor learning and specifically addresses the involvement of somatosensory cortical networks in motor learning of speech. Previous studies in the literature have highlighted the plasticity of cortical sensory networks, notably the primary and secondary somatosensory cortex and the ventral premotor cortex, during motor learning tasks. The present project focuses on the somatosensory region with connections to the sensorimotor regions of the frontal and parietal cortex. We propose to use neuroimaging (fMRI), in order to verify which areas in the prefrontal cortex are part of the sensorimotor network used in the learning of speech motor tasks in humans. Subjects will be tested in the fMRI scanner while performing either a behavioral task in which the auditory feedback of their own speech is altered or while performing a vibrotactile discrimination task.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adaptation to altered auditory feedback | Experimental | fMRI measurement of brain activity during speech production under altered auditory feedback |
|
| Speech production | Experimental | fMRI measurement of brain activity during normal speech production |
|
| Vibrotactile discrimination | Experimental | fMRI measurement of brain activity during a vibrotactile discrimination task |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Speech adaptation | Behavioral | Sensorimotor adaptation in speech |
|
| Measure | Description | Time Frame |
|---|---|---|
| Motor Learning | Learning is assessed as percentage change in speech sounds (speech formant frequencies) relative to baseline. | Performance as measured at the end of learning (during the 1h30 scanner session) |
| Brain activity | Brain activity are measure by the BOLD signal during both task-based and resting-state blocks | 1h30 scanner session |
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Inclusion Criteria:
Exclusion Criteria:
Left-handed subjects
Criteria for contraindications to protocol fMRI scans
Existence of a severe general condition: cardiac, respiratory, hematological, renal, hepatic, cancerous.
Hearing, language (including dyslexia), neurological or psychiatric disorders.
Participation in other ongoing intervention research protocols with exclusionary period or within the previous week
Drug treatment likely to modulate brain activity: benzodiazepines, antidepressants, neuroleptics, lithium, etc.
Protected persons referred to in articles L1121 5 to L1121 8 of the French CSP:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Grenoble-Alpes | Grenoble | 38043 | France |
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| ID | Term |
|---|---|
| D013060 | Speech |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D014705 | Verbal Behavior |
| D003142 | Communication |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D013071 | Speech, Alaryngeal |
| ID | Term |
|---|---|
| D012049 | Rehabilitation of Speech and Language Disorders |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Vibrotactile Discrimination | Behavioral | Vibrotactile Discrimination |
|
| fMRI | Other | fMRI measurement of brain activity |
|
| Speech production | Behavioral | Speech production task |
|
| D005791 | Patient Care |
| D013812 | Therapeutics |