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| ID | Type | Description | Link |
|---|---|---|---|
| R01DC017439 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| McGill University | OTHER |
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
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These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.
Subjects will train using either altered somatosensory feedback or altered auditory feedback (different groups of subjects). Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds or movements relative to baseline. Retention is measured on a 0 to 100 scale relative to the end of learning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Adaptation to Altered Sensory Feedback + cTBS to S1 | Experimental | Adaptation to Altered Sensory Feedback + cTBS to S1 |
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| Adaptation to Altered Sensory Feedback + cTBS to A1 | Experimental | Adaptation to Altered Sensory Feedback + cTBS to A1 |
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| Adaptation to Altered Sensory Feedback + cTBS to M1 | Experimental | Adaptation to Altered Sensory Feedback + cTBS to M1 |
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| Adaptation to Altered Sensory Feedback + Sham cTBS | Experimental | Adaptation to Altered Sensory Feedback + Sham cTBS |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adaptation | Behavioral | Sensorimotor adaptation in speech |
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| Measure | Description | Time Frame |
|---|---|---|
| Motor Learning | Learning is assessed as percentage change in speech sounds (speech formant frequencies) or movements (movement curvature) relative to baseline. | Performance as measured at the end of learning (30 minute session) |
| Retention of Learning | Retention is measured on a 0 to 100 scale relative to the end of learning. | 24 hours after learning (re-test lasts 30 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David Ostry | Haskins Laboratories | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| McGill University | Montreal | Quebec | H3A1G1 | Canada |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Jul 31, 2019 | Mar 19, 2021 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D013060 | Speech |
| ID | Term |
|---|---|
| D014705 | Verbal Behavior |
| D003142 | Communication |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D000064 | Acclimatization |
| ID | Term |
|---|---|
| D000222 | Adaptation, Physiological |
| D010829 | Physiological Phenomena |
| D000220 | Adaptation, Biological |
| D001686 | Biological Phenomena |
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| cTBS | Other | continuous theta-burst stimulation |
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