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The aims of this study is to evaluate the role of 2D speckle-tracking echocardiography in diagnosis chemotherapy related left ventricular dysfunction in breast cancer patients with cardiovascular risks
Chemotherapy induced cardiomyopathy is a serious adverse effect of anticancer treatments with poor long-term prognosis. In addition to the cumulative dose of anthracycline and trastuzumab, cardiovascular risks have been proven to be the "second hit" when dealing with chemotherapy related cardiomyopathy in breast cancer patients. Speckle-tracking echocardiography have had robust evidence in diagnosis the early stage of left ventricular dysfunction in various types of cancer treated by cardiotoxicity drugs. However, data is still lacking regarding the role of speckle-tracking echocardiography in breast cancer patients with cardiovascular risk
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Diagnostic Test | 2D Speckle-tracking echocardiography |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of chemotherapy induced cardiomyopathy in breast cancer patients with cardiovascular risk | the incidence | two year follow-up |
| The kinetics of left ventricular global longitudinal strain (LV-GLS) in breast cancer patients treated by anthracycline and/or trastuzumab | global longitudinal strain (percentage) | two year follow-up |
| The cut-off value of global longitudinal strain (GLS) to predict chemotherapy induced cardiomyopathy in breast cancer patients treated by anthracycline and/or trastuzumab | global longitudinal strain (percentage) | two year follow-up |
| The kinetics of right ventricular longitudinal strain (RV-GLS and RV-FWLS) in breast cancer patients treated by anthracycline and/or trastuzumab | longitudinal strain (percentage) | two year follow-up |
| The kinetics of left atrial longitudinal strain (LASr, LAScd, LASct) in breast cancer patients treated by anthracycline and/or trastuzumab | longitudinal strain (percentage) | two year follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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Breast cancer patients treated by anthracycline and/or trastuzumab with at least one of the cardiovascular risk factors
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nhat M. Giang, M.D | Contact | +84919963999 | minhnhat210189@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hai H. Nguyen, Ph.D | Cardiology Department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nguyen Hoang Hai | Recruiting | Ho Chi Minh City | Vietnam |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D017437 |
| Skin and Connective Tissue Diseases |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |