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The aim of this study is to compare the degree of change in the angle of the vocal cords before and after administration of neostigmine or sugammadex. Moreover, we intend to compare the angle of vocal folds after administration of neostigmine or sugammadex.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sugammadex | Experimental | Administration of Sugammadex |
|
| Neostigmine | Active Comparator | Administration of Neostigmine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sugammadex | Drug | Administration of Sugammadex for muscle relaxation reversal |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Angle of vocal folds after administration of sugammadex or neostigmine 2) Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine | 1-2 minutes after drug administration (inhalation, exhalation) | |
| Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine | 1) Just before drug administration 2) 1-2 minutes after drug administration (inhalation, exhalation) |
| Measure | Description | Time Frame |
|---|---|---|
| Time to recover from spontaneous breathing | Time taken to recover from spontaneous breathing(6ml/kg or more) after administration of sugammadex or neostigmine | immediately after drug(sugammadex or neostigmine) administration |
| Time to extubation |
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Inclusion Criteria:
1. Adult patients who undergoes elective surgery under general anesthesia with supraglottic airway device.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jeong-Rim Lee | Contact | 82-2-2224-4135 | MANYA@yuhs.ac |
| Name | Affiliation | Role |
|---|---|---|
| Jeong-Rim Lee | Severance Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D000077122 | Sugammadex |
| D009388 | Neostigmine |
| ID | Term |
|---|---|
| D047408 | gamma-Cyclodextrins |
| D003505 | Cyclodextrins |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
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triple (Participant, Care Provider, investigator)
| Neostigmine |
| Drug |
Administration of Neostigmine for muscle relaxation reversal |
|
Time taken to extubation after administration of sugammadex or neostigmine
| immediately after drug(sugammadex or neostigmine) administration |
| D003912 |
| Dextrins |
| D013213 | Starch |
| D005936 | Glucans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D050338 | Phenylammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009861 | Onium Compounds |