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| Name | Class |
|---|---|
| Temple University | OTHER |
| Global Alliance for Improved Nutrition | OTHER |
| Purdue University | OTHER |
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Nutrition supplements have tremendous impact upon the nutritional and developmental status of malnourished children. These products have been designed to be acceptable to children (often by adding nutritive sweeteners to make them more palatable), but to date there has been little rigorous testing of their palatability for infants, toddlers and young children. The overall goal of this project is to investigate whether:
More rigorous pre-testing of nutrition supplements, with a focus on palatability (i.e., observations of behavioral and facial responses to its taste) and its relation to children's acceptance (defined here as consumption), could provide important insights into the capacity for these products to transition from being perceived as "medicine" to being accepted as "food," or part of the usual child diet. A clearer understanding of the relation between observed child indicators of palatability and acceptance, both initially and over time (i.e., repeated exposure effects), is important for predicting the longer-term impacts on children's dietary intake, growth and health. Further, a better grasp of caregiver perceptions of the acceptability of these products, both their child's and their own, is critical in paving the way for overcoming barriers and identifying facilitators associated with longer-term acceptance of these nutritional supplements.
We secondarily will also explore the effects of potential mediators on caregiver persistence and infant acceptance of a sweetened and an unsweetened small-quantity lipid nutrition supplement (SQ-LNS) such as:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Unsweetened Supplement | Infants will receive 10 exposures to the unsweetened small quantity lipid nutritional supplement (SQ-LNS) at home | ||
| Sweetened Supplement | Infants will receive 10 exposures to the sweetened small quantity lipid nutritional supplement (SQ-LNS) at home |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in rate of infant acceptance of sweetened and unsweetened nutritional supplement | Acceptance is measured at the conclusion of each offered bite using an adaptation of the Feeding Infants: Behavior and Facial Expression Coding System (FIBFECS) on a 4-point scale from 0-3 where 0 = refusal and 3 = early acceptance of food | Baseline, Week 2 |
| Change in infant consumption of sweetened and unsweetened nutritional supplement | Consumption of each type of supplement will be measured in grams. The weight of the remainder of each supplement will be subtracted from the initial weight of the supplement prior to offering. The remainder of the supplements offered at home will be frozen and returned to the lab to be weighed. | Baseline up to Week 2 |
| Measure | Description | Time Frame |
|---|---|---|
| Baseline caregivers' perceived ratings of infant liking of sweetened and unsweetened supplements | After feeding each version of the supplement, the caregiver will be instructed to rate how much he/she thought his/her infant liked the supplement by placing a mark on a 100 mm visual analog scale (VAS) ranging from "dislikes extremely" to "likes extremely". The distance of the caregivers' marking on the 100mm line is measured from "dislikes extremely" in mm, with higher measurement values meaning caregivers perceive the infants like the supplement more. |
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Inclusion Criteria:
Exclusion Criteria:
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Infants and toddlers and their caregivers will be recruited for this study via:
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| Name | Affiliation | Role |
|---|---|---|
| Susan L Johnson, PhD | University of Colorado, Denver | Principal Investigator |
| Matthew Greenhawt, MD | University of Colorado, Denver | Principal Investigator |
| Jennifer O Fisher, PhD | Temple University | Principal Investigator |
| Kameron J Moding, PhD | Purdue University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Denver | Aurora | Colorado | 80045 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19576254 | Background | Thompson AL, Mendez MA, Borja JB, Adair LS, Zimmer CR, Bentley ME. Development and validation of the Infant Feeding Style Questionnaire. Appetite. 2009 Oct;53(2):210-21. doi: 10.1016/j.appet.2009.06.010. Epub 2009 Jul 1. | |
| 11693591 | Background | Wardle J, Guthrie CA, Sanderson S, Rapoport L. Development of the Children's Eating Behaviour Questionnaire. J Child Psychol Psychiatry. 2001 Oct;42(7):963-70. doi: 10.1111/1469-7610.00792. |
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Data may be available upon request to the Principal Investigator (SL Johnson)
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| ID | Term |
|---|---|
| D005518 | Food Preferences |
| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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| Baseline |
| Follow up caregivers' perceived ratings of infant liking of sweetened and unsweetened supplements | After feeding each version of the supplement, the caregiver will be instructed to rate how much he/she thought his/her infant liked the supplement by placing a mark on a 100 mm visual analog scale (VAS) ranging from "dislikes extremely" to "likes extremely". The distance of the caregivers' marking on the 100mm line is measured from "dislikes extremely" in mm, with higher measurement values meaning caregivers perceive the infants like the supplement more. | Visit two: change from baseline caregivers' perceived ratings at two weeks |
| Baseline caregivers' perceived acceptability of the sweetened and unsweetened supplements | After feeding each version of the supplement, the caregiver will be instructed to rate how likely they would be to serve each supplement again by placing a mark on a 100 mm visual analog scale (VAS) ranging from "not at all likely" to "extremely likely". The distance of the caregivers' marking on the 100mm line is measured from "not at all likely" in mm, with higher measurement values meaning caregivers are more likely to serve the supplement again. | Baseline |
| Follow up caregivers' perceived acceptability of the sweetened and unsweetened supplements | After feeding each version of the supplement, the caregiver will be instructed to rate how likely they would be to serve each supplement again by placing a mark on a 100 mm visual analog scale (VAS) ranging from "not at all likely" to "extremely likely". The distance of the caregivers' marking on the 100mm line is measured from "not at all likely" in mm, with higher measurement values meaning caregivers are more likely to serve the supplement again. | Visit two: change from baseline caregivers' acceptability ratings at two weeks |
| 34036363 | Derived | Johnson SL, Shapiro ALB, Moding KJ, Flesher A, Davis K, Fisher JO. Infant and Toddler Consumption of Sweetened and Unsweetened Lipid Nutrient Supplements After 2-Week Home Repeated Exposures. J Nutr. 2021 Sep 4;151(9):2825-2834. doi: 10.1093/jn/nxab148. |