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The present study evaluates the effects of bactericidal load reduction after surgical hand scrub antisepsis using the reference antiseptic product propanol-
1 60% as control versus a surgical hand scrub antisepsis with triclosan 0.5% in order to test if pass the standard european norm 12791.
The investigators conducted a crossover clinical trial to evaluate the antiseptic effectiveness of preoperative surgical scrubbing using propan-ol-1 60% by scrub using the reference antiseptic product propan-ol-1 60% as control versus a surgical hand scrub antisepsis with trocilosan 0.5% in order to test if pass the standard european norm 12791. Samples will be taken from the hands of each volunteer after a surgical hands antiseptic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hand antisepsis with propanolol-1 60% | Active Comparator | Effectiveness of pre-surgical hand washing in reducing bacterial load using propanolol-1 60% as control |
|
| Hand antisepsis with triclosan solution | Experimental | Effectiveness of pre-surgical hand washing in reducing bacterial load using triclosan 0.5% solution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Triclosan 0.5 % Topical Solution | Drug | Hand antisepsis by scrub Surgical Hand scrubbing using triclosan 0.5% solution both hands using a sterile disposable surgical scrub brush with plastic bristles on one side and a foam sponge on the other side |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of bacterial load immediately after hand scrub | Participants will scrub with the antiseptic solution vigorously from hand to the wrists according with the standard handscrub procedure | Change from bacterial load at 5 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of bacterial load after 3 hours of hand scrub | Participants will scrub with the antiseptic solution vigorously from hand to the wrists according with the standard handscrub after 3 hours | Change from bacterial load after 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ricardo B Becerro de Bengoa Vallejo, PhD | Universidad Complutense de Madrid | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Facultad de Enfermeria, Fisioterapia y Podologia | Madrid | 28040 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34933701 | Derived | Sante L, Gomez-Lus ML, Martin-Villa C, Becerro-de-Bengoa-Vallejo R, Alou L, Sevillano D. Effect on the reduction of bacterial load after surgical hand antisepsis with triclosan 0.5% compared to triclosan 0.5% followed by 70% alcoholic solution. Infect Control Hosp Epidemiol. 2023 Mar;44(3):517-519. doi: 10.1017/ice.2021.506. Epub 2021 Dec 22. |
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A number will be assigned to each participant
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| ID | Term |
|---|---|
| D014260 | Triclosan |
| D012996 | Solutions |
| D011433 | Propranolol |
| ID | Term |
|---|---|
| D010647 | Phenyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D010636 | Phenols |
| D001555 |
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Crossover design is used
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The samples will be sent to the laboratory with numbers
|
| propanolol | Drug | Hand antisepsis by scrub Surgical Hand scrubbing using Propanolol 60% solution both hands using a sterile disposable surgical scrub brush with plastic bristles on one side and a foam sponge on the other side |
|
|
| Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D004364 | Pharmaceutical Preparations |
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D020005 | Propanols |
| D000588 | Amines |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |