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The investigators conducted a controlled, prospective randomized study to examine the antiseptic efficacy of intraoperative irrigation methods during nail avulsion surgery.
The investigators conducted a controlled, prospective randomized study to examine the antiseptic efficacy of intraoperative scrubbing methods during nail avulsion surgery. The investigators compared intraoperative antiseptic scrubbing using 0.9% saline solution and 0.1% polihexanide. Swab samples were taken from each patient at 5 distinct stages throughout the surgical procedure, and bacterial culture analysis was performed (positive culture rate, total inocula count, reduction of bacterial load, and identification of specific microorganisms).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sterile Saline solution | Experimental | The investigators compared intraoperative antiseptic irrigation using 0.9% saline solution and 0.1% polihexanide. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Polihexanide | Drug | The investigators compared intraoperative antiseptic irrigation using 0.9% saline solution and 0.1% polihexanide. |
|
| Measure | Description | Time Frame |
|---|---|---|
| bacterial count (CFU/cm2) | The percentage of inoculum reduction at the irrigation step was calculated as follows: percentage of inoculum reduction = 100 e (1003 Ii)/Is, where Ii is the bacterial count (CFU/cm2) at the irrigation step and Is is the inoculum (CFU/cm2) at the surgery step. Bacteria were identified using standard laboratory methods. The limit of detection in the nailfold test was 1.33 CFU/cm2. | Participants will be followed until the surgery to heal completely,an expected average of 7 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ricado Becerro de Bengoa Vallejo, PhD | Universidad Complutense de Madrid | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidad Complutense de Madrid | Madrid | Madrid | 28040 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21112671 | Background | Becerro de Bengoa Vallejo R, Losa Iglesias ME, Cervera LA, Fernandez DS, Prieto JP. Efficacy of intraoperative surgical irrigation with polihexanide and nitrofurazone in reducing bacterial load after nail removal surgery. J Am Acad Dermatol. 2011 Feb;64(2):328-35. doi: 10.1016/j.jaad.2010.01.011. Epub 2010 Nov 26. |
| Label | URL |
|---|---|
| University Complutense de Madrid | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 12, 2011 | |
| Reset | Aug 5, 2011 | |
| Release | Aug 9, 2011 | |
| Reset | Sep 9, 2011 | |
| Release | Sep 19, 2011 | |
| Reset | Oct 25, 2011 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 12, 2011 | Aug 5, 2011 | |||
| Aug 9, 2011 |
| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D009260 | Nail Diseases |
| D009263 | Nails, Ingrown |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| C031233 | polihexanide |
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| Sep 9, 2011 |
| Sep 19, 2011 | Oct 25, 2011 |