The investigators conduct an RCT to explore the efficacy of esmolol in patients with septic shock and sepsis.

Severe sepsis, septic shock, and their complications have become the major healthcare problem that affects millions of people each year, resulting in high mortality rates. Septic responses have an extremely complex chain of events including inflammatory and anti-inflammatory processes, humoral and cellular reactions, and cardiocirculatory abnormalities. Esmolol may have some potential in treating septic shock and sepsis. The investigators conduct an RCT to explore the efficacy of esmolol in patients with septic shock and sepsis.

Inclusion Criteria:

• sepsis patients
• HR>100bpm 6h after admission
• with CVC and ScvO2>65%

Exclusion Criteria:

• age <18 years,
• used β-blocker before,
• cardiac dysrhythmias,
• need for an inotropic agent,
• valvular heart disease,
• hemoglobin>6g/L
• pregnancy.