The purpose of this study was to investigate the effect of esmolol on hemodynamic parameters,tissue perfusion and the clinical prognosis of patients with severe sepsis

enrollment:151 patients

Inclusion criteria: (1) age > 18 years; (2) severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock, who (3) mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg; and (4) satisfactory sedation and analgesic treatment, with HR > 100 bpm.

Inclusion Criteria:

• age > 18 years;
• severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock,
• mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg;
• satisfactory sedation and analgesic treatment, with HR > 100 bpm.

Exclusion Criteria:

• pre-existing cardiac dysfunction, valvular heart disease, high-degree atrioventricular block;
• acute or chronic pulmonary heart disease;
• a history of serious asthma;
• chronic renal insufficiency;
• cancer, autoimmune diseases, or contraindications for placement of deep venous catheter;
• insulin-dependent diabetes.

151 patients with severe sepsis were selected and divided into the esmolol group (n = 75) or the control group (n = 76)