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The aim of our study is to investigate the pregnancy rates in women with normal uterine cavity ,with and without cervical abnormalities.
The cervix is made up of the ectocervix and endocervix and is on average 3-4 cm long and 2.5 cm wide (Pardo et al., 2003; Mazouni et al., 2005; Robert et al., 2013). The ectocervix is the portion of the cervix projecting into the vagina. It is composed of non-keratinized stratified squamous epithelium and is divided into anterior and posterior lips. The squamocolumnar junction is the area where the epithelial cells of the endocervix and ectocervix meet (Herfs et al., 2013). In this area, the columnar cells of the endocervix undergo metaplasia to the squamous cells of the ectocervix. The opening of the ectocervix to the vagina is called the external os. Although studies of cervical length in non-pregnant women are few, it is acknowledged that the size and shape of both the cervix and the external os differ in women (Pardo et al., 2003; Mazouni et al., 2005) and vary with age, hormonal changes, parity and surgical treatments to the cervix.
Further evaluation of any cervical abnormalities by hysteroscopy eg. (choronic cervicitis , microcycstic epethelium ,micropolypi , cervical stenosis) before ICSI could address us to a hidden cause of infertility and may improve the pregnancy rates in ICSI cycles with prompt medical or surgical managment of such pathologies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group A | women with normal uterine cavity and normal cervix by office hysteroscopy. |
| |
| group B | women with normal uterine cavity with hysteroscopically detected cervical abnormality. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Office Hysteroscopy | Procedure | The hysteroscope with its light source and flowing fluid was gently introduced into the vagina allowing for gradual distention. Once this was accomplished, the anatomy was followed with delicate movements. The hysteroscope was advanced under vision to the level of the ectocervix, and guided into the endocervical canal. Once the endocervical canal was completely explored, the endoscope was advanced across the internal cervical os to allow evaluation of the panoramic view of the uterine cavity. hysteroscopic correction of any detected lesion will be scheduled to the endoscopic operative list or the patient will receive the appropriate medical treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| clinical pregnancy rate | clinical pregnancy rate will be described | 7thweek of prgnancy for cardiac pulsations |
| Measure | Description | Time Frame |
|---|---|---|
| chemical pregnancy rate | chemical pregnancy rate will be described | 4 weeks |
| Abortion rate | Abortion rate either first or second trimester abortion will be documented. |
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Inclusion Criteria:
Exclusion Criteria:
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All infertile women will be assessed in IVF&ICSI unite of Women Health hospital,Assiut university and will be recruted according to the inclusion criteria.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed M. Kamel, MSc&MBBH | Contact | 01003627020 | 002 | ahmedmomen414@yahoo.com |
| Ibrahim I. Mohammed, MD&MSC | Contact | 01001027715 | 002 | ibraheem_hendy@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Women Health Hospital, Assiut University, Egypt | Recruiting | Asyut | 71111 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12768558 | Result | Pardo J, Yogev Y, Ben-Haroush A, Peled Y, Kaplan B, Hod M. Cervical length evaluation by transvaginal sonography in nongravid women with a history of preterm delivery. Ultrasound Obstet Gynecol. 2003 May;21(5):464-6. doi: 10.1002/uog.116. | |
| 16239649 | Result | Mazouni C, Bretelle F, Blanc K, Heckenroth H, Haddad O, Agostini A, Cravello L, Blanc B, Gamerre M. Transvaginal sonographic evaluation of cervix length after cervical conization. J Ultrasound Med. 2005 Nov;24(11):1483-6. doi: 10.7863/jum.2005.24.11.1483. |
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|
| up to 28 weeks |
| preterm labour | preterm labour will be described | 9 months |
| 23623518 | Result | Robert AL, Nicolas F, Lavoue V, Henno S, Mesbah H, Poree P, Leveque J. [Ultrasonographic evaluation of the uterine cervix length remaining after LOOP-excision]. J Gynecol Obstet Biol Reprod (Paris). 2014 Apr;43(4):288-93. doi: 10.1016/j.jgyn.2013.03.014. Epub 2013 Apr 25. French. |
| 23007879 | Result | Herfs M, Vargas SO, Yamamoto Y, Howitt BE, Nucci MR, Hornick JL, McKeon FD, Xian W, Crum CP. A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia. J Pathol. 2013 Feb;229(3):460-8. doi: 10.1002/path.4110. |