Tramadol-paracetamol Combination in Treatment of Patients Undergoing Spinal Surgery

Tramadol-paracetamol Combination in Treatment of Patients Undergoing Spinal Surgery

Tramadol-paracetamol combination is studied in patients coming for elective spine surgery. The study drug is started at the day of surgery and continued maximum of five days. Before the surgery pain, use of pain medication, satisfaction for pain medication, adverse effects, resilience, depression and life satisfaction were asked. At the discharge and seven days after the surgery use of pain medication and adverse effects were asked. The patients were followed up to 28 days and one year after surgery.

Inclusion Criteria:

• age 18-75 years,
• BMI 18-35 kg/m2,
• informed consent obtained,
• elective spine surgery

Exclusion Criteria:

• Age<18 years or >75 years
• Hypersensitivity to anti-inflammatory drugs, paracetamol, tramadol or their auxiliary substances
• Acute or recovered hemorrhage in gastrointestinal tract or peptic ulcer
• Hemorrhagic disease
• Monoamineoxidase use in past two weeks
• Epilepsy
• Tendency to seizure
• Anti-seizure drugs in use Liver or renal failure Reduction in lung function Alcohol, drug or opioid addiction on record Acute intoxication due to alcohol, analgesics, opioids or psychopharmacon Pregnancy or breastfeeding Investigators estimation