Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.

Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.

This research study will investigate the fluid from the area of the brain that is being removed during clinical epilepsy surgery. The goal is to analyze this fluid for inflammatory markers that can potentially help identify new strategies in the future to control seizures in individuals with epilepsy who fail to respond to currently available drugs.

Inclusion Criteria

• Failure to respond to at least two trials of anti-seizure drugs with different mechanisms of action
• Normal MRI

Exclusion Criteria

• Active immunomodulatory therapy
• Autoimmune disorder
• Signs or symptoms consistent with comorbid infection
• Oncological comorbidity