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Presentation, Clinical Course and Patterns of Myocardial Damage due to Viral Myocarditis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients suspected for viral myocarditis | All patients admitted with unexplained heart failure in the last 3 months will be investigated for viral myocarditis by the use of 12 lead ECG, echocardiography, Cardiac MRI , coronary angiography, Endomyocardial biopsy ( optional ), serological tests including ELIZA,Extraction of nucleic acid, Determination of viral genome by using PCR., Quantitative real-time PCR to assess viral load, Immunohistochemistry analysis of EMB. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ELIZA, Extraction of nucleic acid ,Determination of viral genome by using PCR, Quantitative real-time PCR to assess viral load ,Immunohistochemistry analysis of EMB. | Diagnostic Test | ELIZA, Extraction of nucleic acid ,Determination of viral genome by using PCR, Quantitative real-time PCR to assess viral load ,Immunohistochemistry analysis of EMB. |
| Measure | Description | Time Frame |
|---|---|---|
| Determine the pattern of myocarditis in hospitalized patients with acute HF within the last 3 months | All patients admitted with symptoms , signs and echocardiographic finding suggesting myocarditis within 3 months from start of the symptoms. as acute heart failure, arrhythmias, typical chest pain with ST segment deviation in ECG . dilated cardiomyopathy associated with normal Coronary Angiography, history of upper respiratory tract infection within the last 3 months. All will be investigated for determine the pattern of viral myocarditis in those patients | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| determination of the caustive organism | 1. Determine the pattern of broad spectrum cardiotropic viruses in patients with acute HF within the last 3 months. These viruses like enteroviruses, adenoviruses and parvo B19 virus, HBV, HCV and Covid 19 virus due to its increased prevelance nowadays. | 6 months |
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Inclusion Criteria: All patients admitted with symptoms , signs and echocardiographic finding suggesting myocarditis within 3 months from start of the symptoms. as acute heart failure, arrhythmias, typical chest pain with ST segment deviation in ECG . dilated cardiomyopathy associated with normal Coronary Angiography, history of upper respiratory tract infection within the last 3 months.
Exclusion Criteria:
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All patients complained of symptoms of moderate to severe heart disease including atypical chest pain, fatigue, reduced physical capacity, recently occurring cardiac arrhythmia, and/or dyspnea on exertion suggesting myocardial inflammation.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shery Asaad, Resident | Contact | 01270992244 | drshosho31@yahoo.com | |
| Amr yousif, professor | Contact | 01027355511 | amryoussef111@aun.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Ayman khairy, professor | Assiut University | Principal Investigator |
| Mohamed El Mokhtar, professor | Assiut University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shery Refaat Asaad | Recruiting | Asyut | 23123 | Egypt |
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