This study aims to evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient and to correlate it to traditional neurophysiological studies, clinical signs and activity of SLE.

The frequency of SLE peripheral neuropathy documented by electrophysiology has been estimated to be approximately 30%.

The term peripheral neuropathies include symmetric polyneuropathy, single and multiple mononeuropathy, and radiculopathy.

There has been increasing interest in using ultrasonography (US) to aid peripheral neuropathy diagnosis and studies have shown good correlation with other imaging modalities. US is a non-invasive and inexpensive imaging device that has become widely available as a diagnostic tool at many fields.

so systemic lupus patients were enrolled in the study , performed nerve conduction study and neuromuscular ultrasound for bil. median, ulnar, peroneal, tibial and sural nerves , on statistics the cross sections were compared in neurophusiologically affected and non affected nerves, also the sensitivity and specifity of NMUS in comparison to the traditional NCS was calculated

Inclusion Criteria:

1. All adult SLE patients who was admitted to Rheumatology & Rehabilitation department of Assuit university hospital during time frame of study.
2. apparently healthy subjects with normal electrophysiological study
3. verbal consent, free and informed

Exclusion Criteria:

• • Other causes of peripheral neuropathy:

  1. Traumatic
  2. Purely degenerative
  3. Diabetic
  4. Toxic
  5. Infections
  6. Drug induced

All adult SLE patientA who was admitted to Rheumatology & Rehabilitation department of Assuit university hospital during time frame of study. and apparently healthy subjects with normal electrophysiological study

the priciple investigator only will know the results of neurophysiology done to the patients then the images were furtherly evaluated (offline) by another expert rheumatologist who was blinded to both clinical and electrophysiological data of the patients. Any conflict in reporting was refered to a third expert rheumatologist to put the final decision.