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| Name | Class |
|---|---|
| Asan Medical Center | OTHER |
| Severance Hospital | OTHER |
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The purpose of this study is to investigate the pharmacokinetics and pharmacodynamics of dopamine which is used as treatment of hypotension in neonate and preterm infant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dopamine treatment | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dopamine | Drug | Dopamine treatment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Steady state concentration of dopamine (Css) at 2mcg/kg/min | dopamine drug level in blood | After continuous infusion for more than 30 minutes at 2mcg/kg/min |
| Steady state concentration of dopamine (Css) at 5mcg/kg/min | dopamine drug level in blood | After continuous infusion for more than 30 minutes at 5mcg/kg/min |
| Steady state concentration of dopamine (Css) at 10mcg/kg/min | dopamine drug level in blood | After continuous infusion for more than 30 minutes at 10mcg/kg/min |
| Steady state concentration of dopamine (Css) at 15mcg/kg/min | dopamine drug level in blood | After continuous infusion for more than 30 minutes at 15mcg/kg/min |
| Steady state concentration of dopamine (Css) at 20mcg/kg/min | dopamine drug level in blood | After continuous infusion for more than 30 minutes at 20mcg/kg/min |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure in mmHg at 2mcg/kg/min | Systolic, diastolic and mean blood pressure in mmHg | After continuous infusion for more than 30 minutes at 2mcg/kg/min |
| Blood pressure in mmHg at 5mcg/kg/min |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Han-Suk Kim, MD, PhD | Seoul National University Children's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Children's Hospital | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D004298 | Dopamine |
| ID | Term |
|---|---|
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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Systolic, diastolic and mean blood pressure in mmHg
| After continuous infusion for more than 30 minutes at 5mcg/kg/min |
| Blood pressure in mmHg at 10mcg/kg/min | Systolic, diastolic and mean blood pressure in mmHg | After continuous infusion for more than 30 minutes at 10mcg/kg/min |
| Blood pressure in mmHg at 10mcg/kg/min | Systolic, diastolic and mean blood pressure in mmHg | After continuous infusion for more than 30 minutes at 20mcg/kg/min |
| Heart rate | After continuous infusion for more than 30 minutes at 2mcg/kg/min |
| Heart rate | After continuous infusion for more than 30 minutes at 5mcg/kg/min |
| Heart rate | After continuous infusion for more than 30 minutes at 10mcg/kg/min |
| Heart rate | After continuous infusion for more than 30 minutes at 15mcg/kg/min |
| Heart rate | After continuous infusion for more than 30 minutes at 20mcg/kg/min |
| Ejection fraction from Echocardiography | After continuous infusion for more than 30 minutes at 2mcg/kg/min |
| Ejection fraction from Echocardiography | After continuous infusion for more than 30 minutes at 5mcg/kg/min |
| Ejection fraction from Echocardiography | After continuous infusion for more than 30 minutes at 10mcg/kg/min |
| Ejection fraction from Echocardiography | After continuous infusion for more than 30 minutes at 15mcg/kg/min |
| Ejection fraction from Echocardiography | After continuous infusion for more than 30 minutes at 20mcg/kg/min |
| Fractional shortening from Echocardiography | After continuous infusion for more than 30 minutes at 2mcg/kg/min |
| Fractional shortening from Echocardiography | After continuous infusion for more than 30 minutes at 5mcg/kg/min |
| Fractional shortening from Echocardiography | After continuous infusion for more than 30 minutes at 10mcg/kg/min |
| Fractional shortening from Echocardiography | After continuous infusion for more than 30 minutes at 15mcg/kg/min |
| Fractional shortening from Echocardiography | After continuous infusion for more than 30 minutes at 20mcg/kg/min |
| Tei index from Echocardiography | (Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms) | After continuous infusion for more than 30 minutes at 2mcg/kg/min |
| Tei index from Echocardiography | (Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms) | After continuous infusion for more than 30 minutes at 5mcg/kg/min |
| Tei index from Echocardiography | (Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms) | After continuous infusion for more than 30 minutes at 10mcg/kg/min |
| Tei index from Echocardiography | (Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms) | After continuous infusion for more than 30 minutes at 15mcg/kg/min |
| Tei index from Echocardiography | (Mitral valve closure to opening time(ms)-LV ejection time(ms))/LV ejection time(ms) | After continuous infusion for more than 30 minutes at 20mcg/kg/min |
| VTI (velocity time integral) from Echocardiography | the area within the spectral curve and indicates how far blood travels during the flow period | After continuous infusion for more than 30 minutes at 2mcg/kg/min |
| VTI (velocity time integral) from Echocardiography | the area within the spectral curve and indicates how far blood travels during the flow period | After continuous infusion for more than 30 minutes at 5mcg/kg/min |
| VTI (velocity time integral) from Echocardiography | the area within the spectral curve and indicates how far blood travels during the flow period | After continuous infusion for more than 30 minutes at 10mcg/kg/min |
| VTI (velocity time integral) from Echocardiography | the area within the spectral curve and indicates how far blood travels during the flow period | After continuous infusion for more than 30 minutes at 15mcg/kg/min |
| VTI (velocity time integral) from Echocardiography | the area within the spectral curve and indicates how far blood travels during the flow period | After continuous infusion for more than 30 minutes at 20mcg/kg/min |
| D002395 |
| Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |