PK Study of Sildenafil in Neonate

Pharmacokinetic Study of Sildenafil in Neonates and Preterm Infants

The purpose of this study is to investigate the pharmacokinetics of sildenafil which is used as treatment of pulmonary hypertension in neonate and preterm infant.

Inclusion Criteria:

• Admitted at NICU in Seoul National University Hospital or Bundang Seoul National University hospital
• Infants who were diagnosed with PAH

Exclusion Criteria:

• Severe allergic reaction to sildenafil
• Inotropics for hypotension within 3 days prior to enrollment
• AST or ALT > 3x ULN
• Any condition that would make the participant, in the opinion of the investigator, unsuitable for the stud