Effects of Therapeutic Plasmaexhange on Viscoelastic Tests in Non-coagulopathic Patients

Effects of Therapeutic Plasmaexhange on Viscoelastic Tests in Non-coagulopathic Patients

Therapeutic plasma exchange is widely performed in patients with autoimmune disease. The exact effects of fresh frozen plasma on coagulation in this group of patients remains unknown. In order to investigate this issue the present study monitors periprocedural coagulation status with the aid of standard coagulation tests and rotational thromboelastometry. Four thromboelastometric tests will be performed: ExTEM, InTEM, FibTEM and ApTEM. The following parameters will be recorded from each test: CT (sec), CFT (sec) and MCF (mm) one hour before and one hour after plasmaechange was performed.

Inclusion Criteria:

• patients undergoing therapeutic plasma exchange for autoimmune disease

Exclusion Criteria:

• previous coagulation disorders
• anticoagulant or antiplatelet therapy within the last 7 days