Effectiveness of Plasma Transfusions in Critical Care Patients

Effectiveness of Fresh Frozen Plasma in Critical Care (EPICC) Trial

Measuring the effectiveness of plasma transfusions in critical care

Measuring the effectiveness of plasma transfusions in critical care

Inclusion Criteria:

• ICU Admission
• INR > 1.2
• Require FFP for active bleeding and/or prior to an invasive procedure
• Are able to provide consent or proxy consent

Exclusion Criteria:

• Congenital or acquired coagulation factor deficiency
• Platelet count < 50 x 109 /L and have NOT received subsequent platelet transfusion
• Consumptive coagulopathy (bleeding ≥ 3 sites and ↓ plts, ↓ fib, ↑ d dimer)
• Uncontrolled bleeding (6 or more units of blood in the last 6 hours)
• Receiving therapeutic doses of heparin/heparinoid (must be off for at least 6 hours)
• Have received clotting factor concentrates in the previous 24 hours
• Are expected to require surgery in the next 48 hours
• Survival expected to be less than 48 hours
• Currently enrolled in another study with a similar outcome
• Previous enrollment in this study