Impact of Dialysis Modality on Coagulation and Platelet Function

Impact of Dialysis Modality on Coagulation and Platelet Function in Critically Ill Patients: Intermittent Hemodialysis vs. Continuous Renal Replacement Therapy

The investigators will evaluate the impact of dialysis modality (intermittent hemodialysis or continuous renal replacement therapy) in coagulation and platelet function in critically ill patients

An prospective observational study will be conducted to confirm the impact of two dialysis modalitites on coagulation and platelet function in critically ill patients requiring renal replacement therapy using laboratory test, Multiplate and ROTEM.

Inclusion Criteria:

• Critically ill adult patients in surgical intensive care unit who require renal replacement therapy

Exclusion Criteria:

• Patients treated with anti-coagulation therapy due to thrombosis/embolism
• Patients who take anti-platelet drug due to cardiac or cerebrovascular diseased
• Patients treated with pharmacological prophylaxis of deep vein thrombosis
• Patients who received blood products within 24 hours of dialysis initiation
• Patients who do not want life-sustaining care including renal replacement therapy