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Aim of the study is a description of changes in platelet function during continuous veno-venous hemodialysis or hemofiltration in patients on an intensive care unit using the Multiplate system.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dialysis | Platelet function will be documented during the first 48 hours of veno-venous hemofiltration using the Multiplate system. |
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| Measure | Description | Time Frame |
|---|---|---|
| ASPItest | Area under the aggregation curve (AUC) after platelet stimulation with arachidonic acid at baseline and 6, 12, 24 and 48 hours after the start of the continuous hemofiltration. | Baseline, 6, 12, 24 and 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| ADPtest | Area under the aggregation curve (AUC) after platelet stimulation with adenosine diphosphate at baseline and 6, 12, 24 and 48 hours after the start of the continuous hemofiltration. | Baseline, 6, 12, 24 and 48 hours |
| TRAPtest |
| Measure | Description | Time Frame |
|---|---|---|
| Age | Age of the patient at the point of enrollment | Baseline |
| Height | Height of the patient measured in centimeters. | Baseline |
Inclusion Criteria:
Exclusion Criteria:
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Patients in an intensive care unit with the need for a renal replacement therapy-
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johann Wolfgang Goethe-University | Frankfurt am Main | Hesse | 60590 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22592187 | Background | Daugirdas JT, Bernardo AA. Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia. Kidney Int. 2012 Jul;82(2):147-57. doi: 10.1038/ki.2012.130. Epub 2012 May 16. |
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Area under the aggregation curve (AUC) after platelet stimulation with thrombin-receptor-activating peptide 6 (TRAP-6) at baseline and 6, 12, 24 and 48 hours after the start of the continuous hemofiltration.
| Baseline, 6, 12, 24, 48 hours |
| CT-INTEM | Clotting time (CT) in the intrinsically activated rotational thrombelastometry (ROTEM) recorded in seconds at baseline and 6, 12, 24 and 48 hours after the start of continuous veno-venous hemofiltration. | Baseline, 6, 12, 24 and 48 hours |
| MCF-INTEM | Maximum clot firmness (MCF) in the intrinsically activated rotational thrombelastometry (ROTEM) recorded in millimeters at baseline and 6, 12, 24 and 48 hours after the start of continuous veno-venous hemofiltration. | Baseline, 6, 12, 24 and 48hours |
| Weight | Weight of the patient measured in kilograms. | Baseline |
| Gender | Baseline |
| ASA-Classification | The ASA-Classification will be determined preoperatively. | Baseline |
| Antiaggregatory Premedication | Antiaggregatory medication taken prior to enrollment wil be recorded in the categories aspirin, clopidogrel, ticagrelor, cumarins and others. | Baseline |
| Dialysis filter | The brand of filter used for the hemofiltration or hemodialysis will be registered. | Basline |
| Anticoagulation for hemofiltration | The anticoagulation used for hemofiltration will be recorded in the categories heparin and calcium citrate. | Baseline |