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| Name | Class |
|---|---|
| Entrinsic Beverage Company LLC | UNKNOWN |
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To determine the effects of amino acids on the rate of water absorption and availability as a precursor fluid for sweat. Young and healthy (male or female) volunteers will take part in three experimental trials. In each trial, volunteers will be given one of two commercially available sports drinks or a commercially available sport drink with added amino acids in a double-blinded, randomised, crossover design. Each drink will be a single 550 mL bolus. All beverages will be labelled with deuterium (D2O). Trials will be compared for temporal accumulation of deuterium in plasma over the course of 60 minutes and in urine (60 min). Whole blood measurements of haemoglobin and haematocrit will also be made and plasma volume changes calculated. It is hypothesised that the amino acid trial will increase the rate of fluid absorption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Commercially Available Sports Drink A | Placebo Comparator | A commercially available sports water, with small amounts of flavouring, sweetener and electrolytes |
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| Commercially Available Sports Drink B | Experimental | A commercially available sports water, with small amounts of flavouring, sweetener and electrolytes. |
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| Commercially Available Sports Drink A with added Amino Acids | Experimental | The same as sports drink A above (a commercially available sports water, with small amounts of flavouring, sweetener and electrolytes), but with the addition of a small amount of amino acids (~0.7 g/100 ml). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Composition of Sports Drink | Other | The composition of sport drinks will be manipulated to determine the effect of drink composition on the appearance of ingested water in body fluid. |
| Measure | Description | Time Frame |
|---|---|---|
| Time at which drink absorption rate was maximum (t1) | Determined from D2O values in venous blood samples collected before and after drink ingestion | 60 minutes |
| Time at which drink absorption rate returned to 0 (t2) | Determined from D2O values in venous blood samples collected before and after drink ingestion | 60 minutes |
| Time at which 50% of drink was absorbed (t1/2) | Determined from D2O values in venous blood samples collected before and after drink ingestion | 60 minutes |
| Maximum absorption rate of drink | Determined from D2O values in venous blood samples collected before and after drink ingestion | 60 minutes |
| Area under the curve for D2O | Determined from D2O values in venous blood samples collected before and after drink ingestion | 60 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma volume | Determined from haemoglobin and haematocrit measures in venous blood samples collected before and after drink ingestion | 60 minutes |
| Plasma osmolality | Determined from venous blood samples collected before and after drink ingestion |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loughborough University | Loughborough | Leicestershire | LE11 3TU | United Kingdom |
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Double-blind, randomised, crossover design
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Double-blind
| 60 minutes |
| Plasma sodium concentration | Determined from venous blood samples collected before and after drink ingestion | 60 minutes |
| Plasma potassium concentration | Determined from venous blood samples collected before and after drink ingestion | 60 minutes |
| Plasma glucose concentration | Determined from venous blood samples collected before and after drink ingestion | 60 minutes |
| Plasma lactate concentration | Determined from venous blood samples collected before and after drink ingestion | 60 minutes |
| Plasma creatinine concentration | Determined from venous blood samples collected before and after drink ingestion | 60 minutes |
| Plasma amino acid concentration | Determined from venous blood samples collected before and after drink ingestion | 60 minutes |
| Urinary D2O concentration | Determined from urine samples collected before and after drink ingestion | 60 minutes |
| Urinary specific gravity | Determined from urine samples collected before and after drink ingestion | 60 minutes |