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In most babies with biliary atresia (BA) bile ducts on the inside and outside of the liver are affected eventually leading to a complete blockage of bile flow from the liver. This in turn causes scarring (fibrosis) in the liver. The surgery called the Kasai procedure and eventually, a liver transplant could treat biliary atresia. However, children with BA have poor liver function, poor renal reserve, and poor ability to regulate water and electrolytes. Therefore, A reasonable and effective perioperative fluid management is more significant. Considering the high chlorine of saline, the liver burden of Lactated Ringer's solution and Acetated Ringer's solution, the Bicarbonate Ringer's solution which composition is similar to plasma, could be the best choice for perioperative fluid management of BA children. Therefore, we hypothesize that compared with other crystalloids, Bicarbonate Ringer's solution is a better choice to maintain water, electrolyte and acid-base balance in BA children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bicarbonate Ringer's Solution | According to the choices of the patients' immediate family members, patients will be divided into Bicarbonate Ringer's Solution. drug dosage form: Solution, Intravenous infusion. the drug dosage frequency and duration were no intervention |
| |
| Other Crystalloid | According to the choices of patients' immediate family members, patients will be divided into Other Crystalloid. drug dosage form: Solution, Intravenous infusion. the drug dosage frequency and duration were no intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bicarbonate Ringer's solution | Drug | According to the choices of the patients' immediate family members, patients will be divided into Bicarbonate Ringer's Solution. no Intervention. |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial blood gas changes | Compared with the baseline, the patient's base excess and pH changes at the operation 1h, operation 2h, and the end of the operation. | 1 day |
| Intraoperative dosage of sodium bicarbonate injection | Patients with acidosis during the operation needs to be corrected with sodium bicarbonate injection. We collect the amount of sodium bicarbonate injection used to correct metabolic acidosis during the operation | 1 day |
| Chlorine concentration | We collected the concentration of chloride ion in the patient's blood and urine during the baseline, the operation and three days after operation | 3 days |
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Inclusion Criteria:
Exclusion Criteria:
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Study Population was diagnosed with biliary atresia, who need Intravenous infusion.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jiexiong Feng, prof. | Contact | 18607187276 | 86- | wangpeipeggy@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Jiexiong Feng | Tongji hospital of huazhong university of science and technology | Principal Investigator |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Aug 7, 2023 | |
| Reset | Mar 8, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Aug 7, 2023 | Mar 8, 2024 |
| ID | Term |
|---|---|
| D001656 | Biliary Atresia |
| ID | Term |
|---|---|
| D001649 | Bile Duct Diseases |
| D001660 | Biliary Tract Diseases |
| D004066 | Digestive System Diseases |
| D004065 | Digestive System Abnormalities |
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| ID | Term |
|---|---|
| C013003 | glutathione-bicarbonate-Ringer solution |
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| Other Crystalloid | Drug | According to the choices of the patients' immediate family members, patients will be divided into other clinical used crystalloid. no Intervention. |
|
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |