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Lactated Ringer(LR) has been extensively used to maintain and replace intravascular volume in a variety of anesthetic procedures. However, the utility of LR in pediatric with hepatic failure undergoing liver transplantation is unclear, because addition of exogenous lactate may increase lactate concentration. In addition,large amounts of normal saline(NS) which does not contain lactate can induce a hyperchloremic metabolic acidosis and have been asociated with adverse effects on kidney injury, coagulation, and death. Accordingly, the investigators performed a double-blinded randomized trial comparing the effects of intraoperative NS or LR on outcomes in pediatric receiving Liver transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lactated ringers solution | Experimental | Participants in this group will receive Lactated Ringer's solution during the intraoperative period. |
|
| Normal saline solution | Experimental | Participants in this group will receive Normal saline solution during the intraoperative period. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactated Ringer | Drug | Patients will be administered Lactated Ringer's solution for intraoperative fluid management. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in lactate level of the lactated ringer group compared to the normal saline group | Baseline serum lactate will be measured after randomization and again after surgery, then every 24 hours for 72 hours | up to 3 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Length of mechanical ventilation | Length of mechanical ventilation in ICU measured in hours | up to 30 days after surgery |
| ICU stay | Days spend in ICU within 30 days |
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Criteria
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| diansan su, Dr. | Contact | +862168383702 | diansansu@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| qi lu, Dr. | Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Renji Hospital | Recruiting | Shanghai | Shanghai Municipality | 200127 | China |
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| ID | Term |
|---|---|
| D000077325 | Ringer's Lactate |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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| Normal saline | Drug | Patients will be administered normal saline for intraoperative fluid management. |
|
| up to 30 days after surgery |
| 30 day mortality | Patient mortality during the first 30 days after surgery | up to 30 days after surgery |