Creatine Supplementation in Autism Spectrum Disorder

The Effects of Creatine Supplementation in Autism Spectrum Disorder: a Randomized Placebo-controlled Trial

Autism Spectrum Disorder (ASD) is accompanied by reduced levels of total creatine in right temporal-parietal junction and other brain regions of interest, and addressing this deficit by exogenous administration of creatine may have beneficial effects on brain metabolism and disease-specific clinical symptoms in patients suffering from ASD.

Inclusion Criteria:

• Age 10 years and above
• Informed consent signed by a parent or legal guardian or legal representative
• Diagnostic and Statistical Manual of Mental Disorders-IV criteria for ASD.

Exclusion Criteria:

• Pregnant or nursing female patients
• Non-pharmacologic therapy
• Current diagnosis of other mental disorder