Mucosal-Associated Invariant T Cells in Cases of Miscarriage

Analysis of Mucosal-Associated Invariant T (MAIT) Cells in Cases of Spontaneous and Recurrent Miscarriage

Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified. Immunological disturbances have been suggested to play an important role.

Previous studies have focused that women with miscarriage have elevated NK cell numbers and activity both in the periphery and in the endometrium. Also, NK cells in women with RSM displayed an imbalance of Killer cell Ig-like receptors (KIRs) in favor of activating KIR leading to an unbalanced activation of dNK cytotoxicity and higher risk of miscarriage.

Inclusion Criteria:

• Regular marital life with the same partner.
• Regularly menstruating before current pregnancy.
• Spontaneous conception.

Exclusion Criteria:

• Women with Polycystic ovarian syndrome or any endocrinal abnormalities like DM, thyroid disorders.
• History of abnormal uterine cavity proved by sonohysterography or hysteroscopy before pregnancy.
• Women with positive consanguinity.