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This study aims to determine the role of serum biomarkers and placental bloodflow in the comprehensive evaluation of the risk for spontaneous abortion
To study the added value (if any) of combining serum markers, immunologic factors, and ultrasound parameters in comprehensively evaluating the risk for spontaneous abortion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Monitoring of pregnancy, including data on:
| ||
| sFlt-1, Doppler and NK cells types group | Monitoring of pregnancy, including data on:
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Markers of ultrasound | Diagnostic Test | CRL, HR, and other ultrasound measurements. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Occurence of a spontaneous abortion | Absent heart rate pulsations on an ultrasound scan | Up to 24 weeks of gestation |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women between 18 and 50 years of age.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Petar N Ignatov, PhD | Contact | 0035988896318 | 00359 | ignatov@orthogyn.com |
| Name | Affiliation | Role |
|---|---|---|
| Petar N Ignatov, PhD | Orthogyn Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Orthogyn Medical and Dental Center | Recruiting | Sofia | 1618 | Bulgaria |
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| ID | Term |
|---|---|
| D000022 | Abortion, Spontaneous |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Immunologic factors | Diagnostic Test | Measurement of NK cells subpopulations types in the maternal serum |
|
| Serum factors | Diagnostic Test | Measuring the maternal serum concentration of sFlt-1, PLGF, glycodelin-A, and other substances. |
|