Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
To observe and evaluate the safety and efficacy of camrelizumab in advanced liver cancer
camrelizumab , a humanized monoclonal antibody against PD-1, has been shown to block the binding of PD-1 to PD-L1, thereby inhibiting the immune escape of tumor cells. It has a high affinity for PD-1 (KD = 3.31 nmol/L), a high acceptor proportion (85% at 200 mg) of circulating T lymphocytes, and binds to epitopes different from Nivolumab and pembrolizumab,Phase 1 clinical trials have shown that camrelizumab is well tolerated and has antitumor activity in patients with advanced solid tumors.camrelizumab has been approved for indication for advanced hepatocellular carcinoma The main objective of this study was to observe and evaluate the safety and efficacy of treatment regiments containing Camrelizumab in advanced liver cancer。 The subjects included people over 18 years old, For men and women with advanced liver cancer confirmed by histopathology or cytology;
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Camrelizumab in the treatment of liver cancer | Other | Camrelizumab intravenous infusion (no need for prophylactic administration), no less than 30 min |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| camrelizumab | Other | camrelizumab 200 mg, intravenous infusion (no need for prophylactic administration), no less than 30 min ,No more than 60 min, one cycle every 2 weeks (14 days) or one cycle every 3 weeks (21 days). Try to complete the administration before the ECG |
| Measure | Description | Time Frame |
|---|---|---|
| Assess Safety as defined by the NCI CTCAE v5.0 | Adverse events as graded by CTCAE v5.0 | From patients participate in the clinical study to 90 days after the end of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| overall survival | 1-year, 3-year, 5-year survival | 5 years |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xu-Feng Zhang, MD,phD | Contact | 86-029-13359260373 | xfzhang125@126.com | |
| Rui Qu | Contact | 86-18681943306 | 1289271841@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi Lyu, MD,phD | First Affiliated Hospital Xi'an Jiaotong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xi'an Jiaotong University | Recruiting | Xi’an | Shanxi | 710061 | China |
Not provided
| ID | Term |
|---|---|
| C000631724 | camrelizumab |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided