Epidural spinal cord stimulation (SCS) is currently regarded as one of the most promising intervention methods to improve motor function in individuals with severe spinal cord injury. In parallel, an increasing number of studies is suggesting that noninvasive SCS can improve spasticity and residual motor control in the same subject population. The present study explores whether single sessions of noninvasive SCS would improve walking performance and ameliorate spasticity in individuals with multiple sclerosis.

Inclusion Criteria:

• confirmed diagnosis of relapsing-remitting, primary- or secondary-progressive MS
• lower-limb spasticity

Exclusion Criteria:

• acute relapse of MS
• other neuromuscular diseases
• active and passive implants at vertebral level T9 or caudally
• dermatological issues at stimulation site
• pregnancy