Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this randomized clinical trial is to compare the efficacy and safety of intraoperative mitomycin C(MMC) combined with limbal conjunctival autograft(LCAG) or conjunctival autograft(CAG) for recurrent pterygium surgery. The investigators will also evaluate particular risk factors related to pterygium recurrence
Intraoperative mitomycin C after pterygium excision is widely used to prevent recurrce of recurrent pterygium. Conjunctival autograft with or without limbal tissue used to cover the bare sclera will efficiently reduce postoperative longstanding epithelial defect.
Patients with recurrent pterygium will be randomly assigned to undertake pterygium excision followed by intraoperative mitomycin C with conjunctival autograft or limbal conjunctival autograft .The patients will be followed at least 12 months. Corneal recurrence is considered as a fibrovascular ingrowth beyond the limbus with conjunctival drag in the area of previous pterygium excision.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group CAG | Active Comparator | After pterygium excision, intraoperative mitomycin c (0.02%) for 5 minutes will be applied topically onto the exposed surgical area and then conjunctival autograft without limbal tissue will be used to cover the bare sclera. |
|
| Group LCAG | Active Comparator | After pterygium excision, intraoperative mitomycin c (0.02%) for 5 minutes will be applied topically onto the exposed surgical area and then limbal conjunctival autograft will be used to cover the bare sclera. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pterygium excision | Procedure | Partial conjunctiva and anterior tenon's membrane underneath will be removed after the excision of pterygium tissue. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence of pterygium | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity | One year | |
| Healing time of corneal epithelium | Four weeks | |
| Healing time of conjunctival epithelium |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhou Shiyou, M.D., Ph.D. | Contact | 86-02087331540 | zhoushiy@mail.sysu.edu.cn | |
| Zhou Tao, M.D. | Contact | 86-18126813938 | taochou_tony@foxmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhou Shiyou, M.D., Ph.D. | Zhongshan Ophthalmic Center, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center, Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | 510060 | China |
Not provided
| ID | Term |
|---|---|
| D011625 | Pterygium |
| ID | Term |
|---|---|
| D003229 | Conjunctival Diseases |
| D005128 | Eye Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Intraoperative mitomycin C | Procedure | Intraoperative mitomycin C (0.02%) will be applied for 5 minutes after pterygium excision. |
|
|
| Conjunctival autograft | Procedure | A conjunctival autograft will be applied to cover the conjunctival defect after pterygium excision. |
|
|
| Limbal conjunctival autograft | Procedure | A limbal conjunctival autograft will be applied to cover the conjunctival defect after pterygium excision. |
|
|
| Four weeks |
| Postoperative complications | One year |