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To observe the effect of micro-conjunctival autografting combined with amniotic membrane transplantation on the postoperative recurrence, complications and ocular surface symptoms among patients with recurrent pterygium.
Recurrent pterygium is a common postoperative complication of pterygium surgery, the postoperative recurrence rate is about 1.44% and needs careful treatment. At present, surgical is the main and most effective treatment of recurrent pterygium. Among various surgical methods, autologous conjunctival transplantation is regarded as the first choice in normal conditions. However, the scope of conjunctival transplantation is positively correlated with the degree of ocular surface damage. Therefore, our research aimed to use micro conjunctival transplantation（1.5mm×3.0mm） to reconstruct limbal conjunctiva and amniotic membrane to cover the whole pterygium resection area to better protect conjunctival sac and ocular surface.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| experimental group | Experimental | The experimental group received micro-conjunctival autograft combined with amniotic membrane transplantation. |
|
| control group | Active Comparator | The control group received given routine autologous conjunctival transplantation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Micro-Conjunctival Autograft Combined with Amniotic Membrane Transplantation | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes of grade of conjunctival hyperplasia | Grade 1, no significant difference from normal eyes (no recurrence); Grade 2, a little episcleral vessels in the pterygium excision area, which extends to the corneoscleral limbus but does not exceed, and there is no fibrous tissue hyperplasia (no recurrence); Grade 3, having proliferative fibrous tissue in the resection area, which does not exceed the limbus (no recurrence); Grade 4, the cornea is invaded by proliferative fibrous tissue, and this grade is true pterygium recurrence (recurrence). | Day 0#3#7 and14, Month 1#3 and 6. |
| Changes of Schirmer test I | 5-minute Schirmer test I | Day 0#3#7 and14, Month 1#3 and 6. |
| Changes of ocular surface symptom scores | Include dryness, burning, foreign body and pain sensation. The full score of each symptom is 100 points, with a score of 0 reflecting no discomfort, 100 was considered as the maximum discomfort. | Day 0#3#7 and14, Month 1#3 and 6. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of corneal epithelial repair time | Corneal fluorescein sodium staining was applied to assess the epithelial repair after operation. | Day 0#3#7 and14, Month 1#3 and 6. |
| Changes of visual acuity |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of pterygium size | The pterygium size is recorded by the longest length of its invasion into the cornea. | Day 0#3#7 and14, Month 1#3 and 6. |
| Changes of intraocular pressure | To monitor intraocular pressure during the period of useing glucocorticoids. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Second Affiliated Hospital of Nanchang University | Nanchang | Jiangxi | 330000 | China |
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|
| Conventional Autologous Conjunctival Transplantation | Procedure |
|
|
To observe the changes of visual acuity around operation.
| Day 0#3#7 and14, Month 1#3 and 6. |
| Day 0#3#7 and14, Month 1#3 and 6. |
| ID | Term |
|---|---|
| D011625 | Pterygium |
| ID | Term |
|---|---|
| D003229 | Conjunctival Diseases |
| D005128 | Eye Diseases |
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