Quantitative US for Evaluation of Hepatic Steatosis in NAFLD

The Diagnostic Performance Assessment of Quantitative Ultrasound Imaging Indices for Differentiating Hepatic Steatosis Grade in Patients With Non-alcoholic Fatty Liver Disease

The purpose of this study is to evaluate diagnostic performance of quantitative ultrasonographic parameters for the assessment of hepatic steatosis with find optimal cut-off values in patients with non-alcoholic fatty liver disease using magnetic resonance imaging proton density fat fraction (MRI-PDFF) and MR spectroscopy as the reference standard.

Inclusion Criteria:

• patients with known NAFLD or suspected of having NAFLD
• Patients who are scheduled hepatectomy for living donor liver donation
• aged ≥ 18 years who are willing and able to complete all procedures

Exclusion Criteria:

• excessive alcohol consumption within 2 years (40g/day for men, 20g/day for women)
• clinical, laboratory, or histologic evidence of a liver disease other than NAFLD, including viral hepatitis, autoimmune hepatitis, or genetic or acquired disorders
• use of steatogenic or hepatotoxic medication
• evidence of decompensated liver disease
• history of liver surgery
• contraindication to MRI
• any other condition believed by investigator to affect a patients' compliance, or completion of the study