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Approximately 15% of patients with SARS-CoV-2 infection / COVID-19 develop a severe clinical course. This leads to hospitalization and potentially life threatening complications such as pneumonia and respiratory failure. Predictors for early detection and risk stratification are urgently needed. Moreover, only scarce information is available for long-term follow-up and late complications associated with infection. We therefore aimed to find predictors for severe courses of the novel disease as well as to establish strategies for therapeutic monitoring and follow-up.
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| Measure | Description | Time Frame |
|---|---|---|
| TLCO | Transfer factor for carbon monoxide | 3-5 days intervals (inpatients) |
| TLCO | Transfer factor for carbon monoxide | 1-6 months (outpatients, follow up) |
| D5-20 | frequency dependence of resistance as measured by oscillometry | 3-5 days intervals (inpatients |
| D5-20 | frequency dependence of resistance as measured by oscillometry | 1-6 months (outpatients, follow up) |
| FEV1/FVC | forced expiratory volume in 1 s / forced vital capacity (as measured by spirometry) | 3-5 days intervals (inpatients) |
| FEV1/FVC | forced expiratory volume in 1 s / forced vital capacity (as measured by spirometry) | 1-6 months (outpatients, follow up) |
| Measure | Description | Time Frame |
|---|---|---|
| comorbidities | structured questionnaire | at hospital admission and each follow (every 1-6 months) |
| clinical symptoms | structured qualitative questionnaire |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with SARS-CoV-2 infection / COVID 19
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Frederik Trinkmann, MD | Contact | +49 6221 396 | 1201 | frederik.trinkmann@med.uni-heidelberg.de |
| Name | Affiliation | Role |
|---|---|---|
| Frederik Trinkmann, MD | Thoraxklinik at Heidelberg University | Principal Investigator |
| Felix JF Herth, MD | Thoraxklinik at Heidelberg University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thoraxklinik at Heidelberg University | Recruiting | Heidelberg | 69126 | Germany |
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| 3-5 days intervals (inpatients), 1-6 months (outpatients, follow up) |
| St. George's Respiratory Questionnaire total score | validated questionnaire (scores range from 0 to 100, with higher scores indicating more limitations) | 3-5 days intervals (inpatients), 1-6 months (outpatients, follow up) |