Validation of the Neuropsychiatric Fluctuations Scale (EFN-VALID))

French Validation Study of a New Scale for Neuropsychiatric Fluctuations in Parkinson Disease

Neuropsychiatric fluctuations (NF) are among the most disabling non motor fluctuations in Parkinson disease (PD). The investigators developed the NF-scale for acute assessment of non-motor neuropsychiatric fluctuations between the off- and on-medication conditions in PD. The main goal of this project is to validate the NF-scale in french language in a multicenter approach.

Anxiety, sadness, lack of energy and motivation, fatigue and pain are common during the off-medication condition, whereas euphoria, well-being, impulse control disorders, behavioral addictions, mania, and psychosis might occur during the on-medication condition. Early diagnosis of NpsyF is crucial for their holistic management. Unfortunately, NpsyF are often under-recognized by patients or misdiagnosed by physicians due to the lack of specific assessment tools. The NFS is composed of 20 items among which ten measure the "ON neuropsychological state" and ten, the "OFF neuropsychological state". It provides two sub-scores (one ON and one OFF) with a maximal total score of 30.

Inclusion Criteria:

• Idiopathic Parkinson's disease
• presence of motor fluctuations, requiring a levodopa test
• french native speaker

Exclusion Criteria:

• Dementia (MoCa < 24)
• Parkinson syndrome other than idiopathic PD
• people excluded according to french law (including pregnant women or nursing mothers, ...)