Prospective observational study in patients undergoing intra-arterial ophthalmic artery chemotherapy for the treatment of retinoblastoma. The main objective of the study is to evaluate the incidence of cardiorespiratory autonomic reflexes in these patients and to investigate the association between autonomic reflexes and perioperative clinical characteristics.

Inclusion Criteria:

• All patients diagnosed with retinoblastoma and submitted to intra-arterial chemotherapy during the study period
• Informed consent form signed and dated by legal guardian and investigator
• Informed assent form signed by the patient if appropriate

Exclusion Criteria:

• Refusal of the patient or guardian to participate in the research project

Children undergoing cancer treatment for unilateral or bilateral retinoblastoma at the Instituto de Oncologia Pediátrica da Universidade Federal de São Paulo - GRAACC, São Paulo - Brasil.