Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma

Phase II study of selective intra-arterial infusion of chemotherapy for intraocular retinoblastoma

Inclusion Criteria:

1. Patients diagnosed with advanced intraocular retinoblastoma (International Retinoblastoma Classification group D or E*).
2. Patients with tumor recurrence or vitreous seeding following completion of systemic chemotherapy or previous radiation therapy.

Exclusion Criteria:

1. Congenital brain anomaly identified on MRI.
2. History of systemic coagulopathy.
3. Evidence of extra ocular retinoblastoma on clinical examination or neuroimaging.