Study Pilot - Hybrid EEG/fMRI Neurofeedback in Depressed Patients
Study Pilot - Hybrid EEG/fMRI Neurofeedback in Depressed Patients
Cognitive impairment is a common residual symptom after a depressive episode and expose patients to a risk of relapsing or therapeutic resistance.
Neurofeedback (using ElectroEncephaloGraphy - EEG or functional Magnetic Resonance Imaging - fMRI) allows patients to self-regulate their cerebral activity, which is supposedly provided through an intelligible and motivating feedback.
Recent results exhibited clinical improvement in depressed patients who underwent a fMRI neurofeedback protocol targeting the amygdala. Furthermore, prefrontal alpha activity was temporally correlated to variations of the BOLD signal in the amygdala. Simultaneous fMRI/EEG neurofeedback is hypothesized to potentialize its antidepressant effect.
Our objective will be to test this assumption by conducting a double-blind randomized trial, and to prove the superiority of bimodal fMRI/EEG neurofeedback over fMRI neurofeedback alone in depressed patients.
An original visual feedback will be provided and validated beforehand by a pilot study.
Inclusion Criteria:
Exclusion Criteria:
Related to the volunteer
Prior experience of a neurofeedback task
Related to the MRI
Implanted cardiac pacemaker of defibrillator
Brain aneurysm clip
Cochlear implant
Ocular on encephalic metallic foreign body
Endoprothesis implanted for less than 4 weeks and ostheosynthesis device implanted for less than 6 weeks.
Claustrophobia
Other criteria
Unstable hemodynamic status
Acute respiratory failure
Alteration of general state or continuous monitoring requirement
Other psychiatric condition (DSM-5) such as schizophrenia, substance abuse…
Neurological condition or diagnosis of dementia in medical history
Undergoing treatment by benzodiazepines or anticonvulsants prescribed less than a month prior to inclusion
Undergoing treatment influencing the blood flow prescribed less than three weeks prior to inclusion
Protected person (adults legally protected (under judicial protection, guardianship or supervision), person deprived of their liberty, pregnant woman, lactating woman and minor)