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Study aims to compare the influence of intravenous lidocaine and peridural ropivacaine on postoperative long and short term outcome in patients with pancreatic cancer undergoing surgery.
As short term endpoints: postoperative complications and resumption of bowel function.
Long term endpoints include: 1 and 3 year recurrence and mortality.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intravenous lidocaine | Active Comparator | Patients will be subjected to anesthesia with sevoflurane+fentanyl+intravenous lidocaine infusion for the first 48 hours postoperative |
|
| Epidural ropivacaine | Active Comparator | Patients will be subjected to anesthesia with sevoflurane+fentanyl+epidural ropivacaine infusion for the first 48 hours postoperatively |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intravenous lidocaine | Drug | Intraoperatively and postoperatively a standard intravenous infusion of lidocaine will be used for analgesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| 1- and 3-years recurrence rate after surgery | Study participants will be contacted by study team via phone or e-mail | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| 1- and 3-years survival after surgery | Study participants will be contacted by study team via phone or e-mail | 3 years |
| Lidocaine and ropivacaine concentration | Intraoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Theodor Bot, PhD Student | Contact | 0040765350176 | theo_bot@yahoo.com | |
| Daniela Ionescu, MD PhD | Contact | 0744771209 | dionescuati@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Daniela Ionescu, MD PhD | Regional Institute of Gastroenterology and Hepatology Prof. Dr. O. Fodor | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Regional Institute of Gastroenterology and Hepatology "Prof. Dr. O. Fodor" | Cluj-Napoca | Romania |
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| Epidural ropivacaine | Drug | Intraoperatively and postoperatively an epidural infusion of ropivacaine will be used for analgesia |
|
| Complication rate after surgery | Resumption of bowel function, anastomotic leakage or hemorrhage | 2 weeks |
| ID | Term |
|---|---|
| D010190 | Pancreatic Neoplasms |
| ID | Term |
|---|---|
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004701 | Endocrine Gland Neoplasms |
| D004066 | Digestive System Diseases |
| D010182 | Pancreatic Diseases |
| D004700 | Endocrine System Diseases |
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