Influence of Local Anesthetic Administration on the Cancer Recurrence Rate After Pancreatic Oncologic Surgery

Influence of Local Anesthetic Administration on the Cancer Recurrence Rate After Pancreatic Oncologic Surgery

Study aims to compare the influence of intravenous lidocaine and peridural ropivacaine on postoperative long and short term outcome in patients with pancreatic cancer undergoing surgery.

As short term endpoints: postoperative complications and resumption of bowel function.

Long term endpoints include: 1 and 3 year recurrence and mortality.

Inclusion Criteria:

• diagnosis of pancreatic cancer
• American Society of Anesthesiologists (ASA) risk I - III

Exclusion Criteria:

• chronic pain
• chronic medication that may interfere with pain: antiepileptics, NSAID, corticoids
• contraindications for any of the study medications
• significant psychiatric disorders (major depression, bipolar disorders, schizophrenia, etc.)
• Convulsive disorders requiring medication during the last 2 years
• liver cirrhosis/chronic kidney disease stage IV or V/chronic heart failure class III or IV/ decompensated diabetes
• Corticoid dependent asthma
• Autoimmune disorders
• Anti-arrhythmic medication (verapamil, propafenone, amiodarone) that may interfere with lidocaine's anti-arrhythmic effects
• Refusal for study participation